BIRC6

This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination.

baculoviral IAP repeat containing 6

Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification.

Apoptotic process Source: UniProtKB-KW
Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Labyrinthine layer development Source: Ensembl
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of extrinsic apoptotic signaling pathway Source: UniProtKB
Positive regulation of cell population proliferation Source: Ensembl
Protein phosphorylation Source: UniProtKB
Protein ubiquitination Source: UniProtKB
Regulation of cell population proliferation Source: UniProtKB
Regulation of cytokinesis Source: UniProtKB
Spongiotrophoblast layer development Source: Ensembl
Ubiquitin-dependent protein catabolic process Source: GO_Central

Trans-Golgi network membrane; Spindle pole; Centrosome; Endosome; Midbody ring. Exhibits cell cycle-dependent localization. Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis. On the midbody, localizes to the midbody ring, also called Flemming body (PubMed:18329369). In interphase cells, localizes to the trans-Golgi network membrane and endosomes. During cytokinesis, a fraction moves to the midzone where it specifically arrives at the midbody ring. After abscission completion, travels with the midbody remnant into one daughter cell, and remains bound to it until a new midbody ring is formed during the next cell division (PubMed:18329369).

Ubiquitinated. Ubiquitination is mediated by the RNF41 E3 ligase and leads to proteasomal degradation, impairing inhibition of apoptosis. Deubiquitinated by USP8/UBPY.