BNC1

The protein encoded by this gene is a zinc finger protein present in the basal cell layer of the epidermis and in hair follicles. It is also found in abundance in the germ cells of testis and ovary. This protein is thought to play a regulatory role in keratinocyte proliferation and it may also be a regulator for rRNA transcription. This gene seems to have multiple alternatively spliced transcript variants, but their full-length nature is not known yet. There seems to be evidence of multiple polyadenylation sites for this gene. [provided by RefSeq]

basonuclin 1

Transcriptional activator (By similarity).
It is likely involved in the regulation of keratinocytes terminal differentiation in squamous epithelia and hair follicles (PubMed:8034748).
Required for the maintenance of spermatogenesis (By similarity).
It is involved in the positive regulation of oocyte maturation, probably acting through the control of BMP15 levels and regulation of AKT signaling cascade (PubMed:30010909).
May also play a role in the early development of embryos (By similarity).

Cell differentiation Source: UniProtKB-KW
Epidermis development Source: ProtInc
Positive regulation of cell population proliferation Source: ProtInc
Positive regulation of oocyte maturation Source: UniProtKB
Positive regulation of transcription by RNA polymerase I Source: ARUK-UCL
Regulation of transcription, DNA-templated Source: GO_Central
Regulation of transcription by RNA polymerase I Source: GO_Central
Spermatogenesis Source: UniProtKB-KW

Cytoplasm; Nucleus; Nucleoplasm. Relocates to the midpiece of the flagellum during late spermiogenesis in spermatids.

Premature ovarian failure 16 (POF16): An autosomal dominant form of premature ovarian failure, an ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.

Phosphorylation on Ser-537 and Ser-541 leads to cytoplasmic localization.