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CA8

The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. Mutations in this gene are associated with cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3 (CMARQ3). Polymorphisms in this gene are associated with osteoporosis, and overexpression of this gene in osteosarcoma cells suggests an oncogenic role. Alternative splicing results in multiple transcript variants.
Full Name
CA8
Function
Does not have a carbonic anhydrase catalytic activity.
Biological Process
One-carbon metabolic process Source: GO_Central
Phosphatidylinositol-mediated signaling Source: Ensembl
Cellular Location
Cytoplasm
Involvement in disease
Cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3 (CMARQ3): A congenital cerebellar ataxia associated with dysarthia, quadrupedal gait and mental retardation.
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Anti-CA8 antibodies

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Mouse Anti-CA8 Recombinant Antibody (CBLC045-LY) (CBMAB-C9592-LY)

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Target: CA8
Host: Mouse
Antibody Isotype: IgG2a, ĸ
Specificity: Human, Mouse, Rat
Clone: CBLC045-LY
Application*: E, WB, IF, IP, P
Datasheet SDS

Mouse Anti-CA8 Recombinant Antibody (1BA9) (CBMAB-1041CQ)

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Target: CA8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1BA9
Application*: E
Datasheet SDS

Rabbit Anti-CA8 Recombinant Antibody (CBFYC-0704) (CBMAB-C0758-FY)

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Target: CA8
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYC-0704
Application*: WB, IP
Datasheet SDS

Rabbit Anti-CA8 Recombinant Antibody (CBFYC-0703) (CBMAB-C0757-FY)

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Target: CA8
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-0703
Application*: WB, IP
Datasheet SDS

Mouse Anti-CA8 Recombinant Antibody (CBFYC-0702) (CBMAB-C0756-FY)

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Target: CA8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Horse, Dog, Pig
Clone: CBFYC-0702
Application*: E, WB, IF, IP
Datasheet SDS

Mouse Anti-CA8 Recombinant Antibody (CBFYC-0701) (CBMAB-C0755-FY)

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Target: CA8
Host: Mouse
Antibody Isotype: IgG2a, ĸ
Specificity: Human, Mouse, Rat
Clone: CBFYC-0701
Application*: E, WB, IF, IP
Datasheet SDS

Rabbit Anti-CA8 Recombinant Antibody (057) (CBMAB-C1793-LY)

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Target: CA8
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 057
Application*: E
Datasheet SDS

Rabbit Anti-CA8 Recombinant Antibody (001) (CBMAB-C1441-LY)

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Target: CA8
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 001
Application*: E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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