CACTIN

CACTIN (Cactin, Spliceosome C Complex Subunit) is a Protein Coding gene.

Full Name

Cactin, Spliceosome C Complex Subunit

Function

Involved in the regulation of innate immune response (PubMed:20829348).
Acts as negative regulator of Toll-like receptor, interferon-regulatory factor (IRF) and canonical NF-kappa-B signaling pathways (PubMed:20829348, PubMed:26363554).
Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli (PubMed:20829348, PubMed:26363554).

Biological Process

Cellular response to interleukin-1 Source: UniProtKB
Cellular response to lipopolysaccharide Source: UniProtKB
Cellular response to tumor necrosis factor Source: UniProtKB
Innate immune response Source: UniProtKB-KW
mRNA cis splicing, via spliceosome Source: GO_Central
mRNA splicing, via spliceosome Source: UniProtKB
Multicellular organism development Source: UniProtKB-KW
Negative regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Negative regulation of innate immune response Source: GO_Central
Negative regulation of interferon-beta production Source: UniProtKB
Negative regulation of interleukin-8 production Source: UniProtKB
Negative regulation of lipopolysaccharide-mediated signaling pathway Source: UniProtKB
Negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
Negative regulation of protein phosphorylation Source: UniProtKB
Negative regulation of toll-like receptor signaling pathway Source: UniProtKB
Negative regulation of tumor necrosis factor production Source: UniProtKB
Negative regulation of type I interferon-mediated signaling pathway Source: UniProtKB
Regulation of gene expression Source: GO_Central

Cellular Location

Nucleus; Cytosol. Nuclear localization with a speckled expression pattern in some cells. Colocalizes with NFKBIL1 in the nucleus.