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Mouse Anti-CACTIN Recombinant Antibody (CBLC055-LY) (CBMAB-C9623-LY)

The product is antibody recognizes CACTIN. The antibody CBLC055-LY immunoassay techniques such as: WB, IP, IF, ELISA.
See all CACTIN antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBLC055-LY
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cactin, Spliceosome C Complex Subunit
Introduction
CACTIN (Cactin, Spliceosome C Complex Subunit) is a Protein Coding gene.
Entrez Gene ID
Human58509
Mouse70312
Rat500790
UniProt ID
HumanQ8WUQ7
MouseQ9CS00
RatB2GUU0
Function
Involved in the regulation of innate immune response (PubMed:20829348).
Acts as negative regulator of Toll-like receptor, interferon-regulatory factor (IRF) and canonical NF-kappa-B signaling pathways (PubMed:20829348, PubMed:26363554).
Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli (PubMed:20829348, PubMed:26363554).
Biological Process
Cellular response to interleukin-1 Source: UniProtKB
Cellular response to lipopolysaccharide Source: UniProtKB
Cellular response to tumor necrosis factor Source: UniProtKB
Innate immune response Source: UniProtKB-KW
mRNA cis splicing, via spliceosome Source: GO_Central
mRNA splicing, via spliceosome Source: UniProtKB
Multicellular organism development Source: UniProtKB-KW
Negative regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Negative regulation of innate immune response Source: GO_Central
Negative regulation of interferon-beta production Source: UniProtKB
Negative regulation of interleukin-8 production Source: UniProtKB
Negative regulation of lipopolysaccharide-mediated signaling pathway Source: UniProtKB
Negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
Negative regulation of protein phosphorylation Source: UniProtKB
Negative regulation of toll-like receptor signaling pathway Source: UniProtKB
Negative regulation of tumor necrosis factor production Source: UniProtKB
Negative regulation of type I interferon-mediated signaling pathway Source: UniProtKB
Regulation of gene expression Source: GO_Central
Cellular Location
Nucleus; Cytosol. Nuclear localization with a speckled expression pattern in some cells. Colocalizes with NFKBIL1 in the nucleus.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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