CARD16

CARD16 (Caspase Recruitment Domain Family Member 16) is a Protein Coding gene. Among its related pathways are Toll-like receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is CARD17.

Full Name

caspase recruitment domain family member 16

Function

Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.

Biological Process

Cellular response to hypoxia Source: UniProtKB
Cellular response to lipopolysaccharide Source: UniProtKB
Cellular response to UV-C Source: UniProtKB
Inhibition of cysteine-type endopeptidase activity Source: UniProtKB
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Negative regulation of interleukin-1 beta production Source: UniProtKB
Negative regulation of lipopolysaccharide-mediated signaling pathway Source: UniProtKB
Negative regulation of protein binding Source: UniProtKB
Negative regulation of tumor necrosis factor-mediated signaling pathway Source: UniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Positive regulation of NF-kappaB transcription factor activity Source: UniProtKB

Cellular Location

Protease inhibitor complex; Protein-containing complex