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Mouse Anti-CARD16 Recombinant Antibody (CBXC-0068) (CBMAB-C5428-CQ)

This product is a mouse antibody that recognizes CARD16. The antibody CBXC-0068 can be used for immunoassay techniques such as: ELISA, WB.
See all CARD16 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-0068
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
caspase recruitment domain family member 16
Introduction
CARD16 (Caspase Recruitment Domain Family Member 16) is a Protein Coding gene. Among its related pathways are Toll-like receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is CARD17.
Entrez Gene ID
114769
UniProt ID
Q5EG05
Alternative Names
Caspase Recruitment Domain Family Member 16; Pseudo Interleukin-1 Beta Converting Enzyme; Caspase Recruitment Domain-Only Protein 1; Pseudo-IL1B-Converting Enzyme; Caspase-1 Inhibitor COP; CARD-Only Protein 1; PSEUDO-ICE; COP1; COP;
Function
Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.
Biological Process
Cellular response to hypoxia Source: UniProtKB
Cellular response to lipopolysaccharide Source: UniProtKB
Cellular response to UV-C Source: UniProtKB
Inhibition of cysteine-type endopeptidase activity Source: UniProtKB
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Negative regulation of interleukin-1 beta production Source: UniProtKB
Negative regulation of lipopolysaccharide-mediated signaling pathway Source: UniProtKB
Negative regulation of protein binding Source: UniProtKB
Negative regulation of tumor necrosis factor-mediated signaling pathway Source: UniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
Cellular Location
Protease inhibitor complex; Protein-containing complex
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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