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CCT2

This gene encodes a molecular chaperone that is member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of the gene described in this record have been observed but have not been thoroughly characterized. [provided by RefSeq]
Full Name
chaperonin containing TCP1, subunit 2 (beta)
Function
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444).
The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444).
As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638).
The TRiC complex plays a role in the folding of actin and tubulin (Probable).
Biological Process
Binding of sperm to zona pellucida Source: Ensembl
Chaperone-mediated protein complex assembly Source: MGI
Chaperone mediated protein folding independent of cofactor Source: BHF-UCL
Neutrophil degranulation Source: Reactome
Positive regulation of establishment of protein localization to telomere Source: BHF-UCL
Positive regulation of protein localization to Cajal body Source: BHF-UCL
Positive regulation of telomerase activity Source: BHF-UCL
Positive regulation of telomerase RNA localization to Cajal body Source: BHF-UCL
Positive regulation of telomere maintenance via telomerase Source: BHF-UCL
Protein folding Source: FlyBase
Protein stabilization Source: BHF-UCL
scaRNA localization to Cajal body Source: BHF-UCL
Toxin transport Source: Ensembl
Cellular Location
Cytoplasm
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Anti-CCT2 antibodies

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Mouse Anti-CCT2 Recombinant Antibody (CBT1193) (V2LY-0625-LY2957)

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Target: CCT2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: CBT1193
Application*: WB, IF, IC, F, E
Datasheet SDS

Mouse Anti-CCT2 Recombinant Antibody (CBT1194) (V2LY-0625-LY2956)

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Target: CCT2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT1194
Application*: WB, E
Datasheet SDS

Mouse Anti-CCT2 Recombinant Antibody (CBT3384) (V2LY-0625-LY2663)

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Target: CCT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3384
Application*: WB
Datasheet SDS

Mouse Anti-CCT2 Recombinant Antibody (CBT2006) (V2LY-0625-LY2655)

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Target: CCT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Monkey, Rat
Clone: CBT2006
Application*: WB, IC, F
Datasheet SDS

Mouse Anti-CCT2 Recombinant Antibody (CBXC-0165) (CBMAB-C5229-CQ)

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Target: CCT2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXC-0165
Application*: E, WB, IF
Datasheet SDS

Rabbit Anti-Cct2 Recombinant Antibody (CBYJT-1070) (CBMAB-T0080-YJ)

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Target: Cct2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYJT-1070
Application*: F, IP, IF, IH, WB
Datasheet SDS

Rat Anti-CCT2 Recombinant Antibody (CBYJT-1069) (CBMAB-T0079-YJ)

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Target: CCT2
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat, Rabbit, Sheep, Cattle, Dog, Hamster, Chicken, Pig, Monkey
Clone: CBYJT-1069
Application*: P, WB
Datasheet SDS

Mouse Anti-CCT2 Recombinant Antibody (CBYJT-1068) (CBMAB-T0078-YJ)

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Target: CCT2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBYJT-1068
Application*: E, IF, IP, WB, P
Datasheet SDS

Mouse Anti-CCT2 Recombinant Antibody (CBYJT-1064) (CBMAB-T0074-YJ)

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Target: CCT2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Dog, Cattle, Pig
Clone: CBYJT-1064
Application*: E, IF, IP, WB
Datasheet SDS

Mouse Anti-CCT2 Recombinant Antibody (CBFYC-1095) (CBMAB-C1152-FY)

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Target: CCT2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat, Frrog
Clone: CBFYC-1095
Application*: P, IF, IP, WB
Datasheet SDS

Mouse Anti-CCT2 Recombinant Antibody (CBFYC-1094) (CBMAB-C1151-FY)

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Target: CCT2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-1094
Application*: E, IF, IP, WB, P
Datasheet SDS

Mouse Anti-CCT2 Monoclonal Antibody (5B5C4) (CBMAB-1627-YC)

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Target: CCT2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat, Monkey
Clone: 5B5C4
Application*: E, IF, F, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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