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Mouse Anti-CCT2 Recombinant Antibody (CBT3384) (V2LY-0625-LY2663)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT3384
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Purified recombinant fragment of human CCT2 expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Preservative
Sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
chaperonin containing TCP1, subunit 2 (beta)
Entrez Gene ID
10576
UniProt ID
P78371
Function
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444).
The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444).
As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638).
The TRiC complex plays a role in the folding of actin and tubulin (Probable).
Biological Process
Binding of sperm to zona pellucida Source: Ensembl
Chaperone-mediated protein complex assembly Source: MGI
Chaperone mediated protein folding independent of cofactor Source: BHF-UCL
Neutrophil degranulation Source: Reactome
Positive regulation of establishment of protein localization to telomere Source: BHF-UCL
Positive regulation of protein localization to Cajal body Source: BHF-UCL
Positive regulation of telomerase activity Source: BHF-UCL
Positive regulation of telomerase RNA localization to Cajal body Source: BHF-UCL
Positive regulation of telomere maintenance via telomerase Source: BHF-UCL
Protein folding Source: FlyBase
Protein stabilization Source: BHF-UCL
scaRNA localization to Cajal body Source: BHF-UCL
Toxin transport Source: Ensembl
Cellular Location
Cytoplasm
More Infomation

Ghozlan, H., Showalter, A., Lee, E., Zhu, X., & Khaled, A. R. (2021). Chaperonin-Containing TCP1 complex (CCT) promotes breast cancer growth through correlations with key cell cycle regulators. Frontiers in oncology, 11.

Li, W., Liu, J., & Zhao, H. (2021). Prognostic Power of a Chaperonin Containing TCP-1 Subunit Genes Panel for Hepatocellular Carcinoma. Frontiers in genetics, 12, 502.

Ghozlan, H. H., Showalter, A., & Khaled, A. R. (2021). Chaperonin-Containing TCP1 complex (CCT) promotes breast cancer by targeting key cell cycle regulators.

Cox, A., Martini, A., Lee, E., Moroose, R., Khaled, A., & Khaled, A. R. (2021). Using chaperonin containing TCP1 as a marker to track clinically relevant circulating tumor cells.

Liu, Q., Qi, Y., Kong, X., Wang, X., Zhang, W., Zhai, J., ... & Wang, J. (2021). Molecular and Clinical Characterization of CCT2 Expression and Prognosis via Large-Scale Transcriptome Profile of Breast Cancer. Frontiers in oncology, 11.

Showalter, A. E., Martini, A. C., Nierenberg, D., Hosang, K., Fahmi, N. A., Gopalan, P., ... & Khaled, A. R. (2020). Investigating chaperonin-containing TCP-1 subunit 2 as an essential component of the chaperonin complex for tumorigenesis. Scientific reports, 10(1), 1-14.

Hallal, S., Russell, B. P., Wei, H., Lee, M. Y. T., Toon, C. W., Sy, J., ... & Kaufman, K. L. (2019). Extracellular vesicles from neurosurgical aspirates identifies chaperonin containing TCP1 subunit 6A as a potential glioblastoma biomarker with prognostic significance. Proteomics, 19(1-2), 1800157.

Carr, A. C., Khaled, A. S., Bassiouni, R., Flores, O., Nierenberg, D., Bhatti, H., ... & Khaled, A. R. (2017). Targeting chaperonin containing TCP1 (CCT) as a molecular therapeutic for small cell lung cancer. Oncotarget, 8(66), 110273.

Li, L. J., Zhang, L. S., Han, Z. J., He, Z. Y., Chen, H., & Li, Y. M. (2017). Chaperonin containing TCP-1 subunit 3 is critical for gastric cancer growth. Oncotarget, 8(67), 111470.

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For research use only. Not intended for any clinical use.

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