CENPC

Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. [provided by RefSeq, Jul 2008]
Full Name
Centromere Protein C
Function
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.
Biological Process
Attachment of mitotic spindle microtubules to kinetochore Source: GO_Central
Cell division Source: UniProtKB-KW
CENP-A containing nucleosome assembly Source: Reactome
Chromosome segregation Source: UniProtKB
Kinetochore assembly Source: UniProtKB
Mitotic cell cycle Source: UniProtKB
Mitotic spindle organization Source: Reactome
Monopolar spindle attachment to meiosis I kinetochore Source: GO_Central
Cellular Location
Nucleus; Kinetochore; Centromere. Localizes exclusively in the kinetochore domain of centromeres.
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Anti-CENPC antibodies

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Rabbit Anti-CENPC Recombinant Antibody (CBFYC-1708) (CBMAB-C1770-FY)

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Target: CENPC
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-1708
Application*: WB, IF
Datasheet SDS

Mouse Anti-CENPC Recombinant Antibody (CBFYC-1707) (CBMAB-C1769-FY)

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Target: CENPC
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-1707
Application*: WB, IP, IF, E
Datasheet SDS

Rabbit Anti-CENPC Recombinant Antibody (C0633) (CBMAB-C0633-LY)

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Target: CENPC
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: C0633
Application*: WB, IP, IF, F, P
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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