Sign in or Register   Sign in or Register
  |  

Mouse Anti-CENPC Recombinant Antibody (2159C5a) (CBMAB-C0633-LY)

This product is antibody recognizes CENPC. The antibody 2159C5a immunoassay techniques such as: DB, WB.
See all CENPC antibodies
Published Data
Fig.1 Knocking down of AGO2, Dicer and CENPC1 with two sets of siRNAs in human RPE-1 cells.
...View More

Summary

Host Animal
Mouse
Specificity
Human
Clone
2159C5a
Antibody Isotype
IgG2b
Application
DB, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
1% BSA
Preservative
0.05% sodium azide
Concentration
0.1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Centromere Protein C
Introduction
Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. [provided by RefSeq, Jul 2008]
Entrez Gene ID
1060
UniProt ID
Q03188
Alternative Names
Centromere Protein C; Centromere Protein C 1; Interphase Centromere Complex Protein 7; Centromere Autoantigen C; CENP-C 1; CENPC1;
Function
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.
Biological Process
Attachment of mitotic spindle microtubules to kinetochore Source: GO_Central
Cell division Source: UniProtKB-KW
CENP-A containing nucleosome assembly Source: Reactome
Chromosome segregation Source: UniProtKB
Kinetochore assembly Source: UniProtKB
Mitotic cell cycle Source: UniProtKB
Mitotic spindle organization Source: Reactome
Monopolar spindle attachment to meiosis I kinetochore Source: GO_Central
Cellular Location
Nucleus; Kinetochore; Centromere. Localizes exclusively in the kinetochore domain of centromeres.

Fan, J., Liu, Y., & Zhong, Y. (2021). Immunization with CENP-C Causes Aberrant Chromosome Segregation during Oocyte Meiosis in Mice. Journal of Immunology Research, 2021.

Fellmeth, J. E., & McKim, K. S. (2020). Meiotic CENP-C is a shepherd: bridging the space between the centromere and the kinetochore in time and space. Essays in biochemistry, 64(2), 251-261.

Chik, J. K., Moiseeva, V., Goel, P. K., Meinen, B. A., Koldewey, P., An, S., ... & Cho, U. S. (2019). Structures of CENP-C cupin domains at regional centromeres reveal unique patterns of dimerization and recruitment functions for the inner pocket. Journal of Biological Chemistry, 294(38), 14119-14134.

McNulty, S. M., Sullivan, L. L., & Sullivan, B. A. (2017). Human centromeres produce chromosome-specific and array-specific alpha satellite transcripts that are complexed with CENP-A and CENP-C. Developmental cell, 42(3), 226-240.

Giunta, S., & Funabiki, H. (2017). Integrity of the human centromere DNA repeats is protected by CENP-A, CENP-C, and CENP-T. Proceedings of the National Academy of Sciences, 114(8), 1928-1933.

Xiao, H., Wang, F., Wisniewski, J., Shaytan, A. K., Ghirlando, R., FitzGerald, P. C., ... & Wu, C. (2017). Molecular basis of CENP-C association with the CENP-A nucleosome at yeast centromeres. Genes & development, 31(19), 1958-1972.

Sandmann, M., Talbert, P., Demidov, D., Kuhlmann, M., Rutten, T., Conrad, U., & Lermontova, I. (2017). Targeting of Arabidopsis KNL2 to centromeres depends on the conserved CENPC-k motif in its C terminus. The Plant Cell, 29(1), 144-155.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-CENPC Recombinant Antibody (2159C5a)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare