CETP

The protein encoded by this gene is found in plasma, where it is involved in the transfer of cholesteryl ester from high density lipoprotein (HDL) to other lipoproteins. Defects in this gene are a cause of hyperalphalipoproteinemia 1 (HALP1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

Full Name

Cholesteryl Ester Transfer Protein

Function

Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL (PubMed:3600759, PubMed:24293641, PubMed:3281933).
Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (PubMed:17237796).

Biological Process

Cholesterol homeostasis Source: BHF-UCL
Cholesterol metabolic process Source: BHF-UCL
Cholesterol transport Source: UniProtKB
High-density lipoprotein particle remodeling Source: UniProtKB
Intracellular receptor signaling pathway Source: Reactome
Lipid homeostasis Source: BHF-UCL
Lipid transport Source: BHF-UCL
Low-density lipoprotein particle remodeling Source: BHF-UCL
Negative regulation of macrophage derived foam cell differentiation Source: BHF-UCL
Phosphatidylcholine metabolic process Source: BHF-UCL
Phospholipid homeostasis Source: BHF-UCL
Positive regulation of cholesterol transport Source: BHF-UCL
Positive regulation of phospholipid transport Source: BHF-UCL
Regulation of cholesterol efflux Source: BHF-UCL
Reverse cholesterol transport Source: BHF-UCL
Triglyceride homeostasis Source: BHF-UCL
Triglyceride metabolic process Source: BHF-UCL
Triglyceride transport Source: UniProtKB
Very-low-density lipoprotein particle remodeling Source: UniProtKB

Cellular Location

Secreted. Secreted in plasma.

Involvement in disease

Hyperalphalipoproteinemia 1 (HALP1): A condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels.