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Mouse Anti-CETP Recombinant Antibody (CBYJL-1017) (CBMAB-L0427-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Cholesteryl Ester Transfer Protein (CETP). The antibody can be used for immunoassay techniques, such as ELISA.
See all CETP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-1017
Antibody Isotype
IgG1
Application
ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cholesteryl Ester Transfer Protein
Introduction
CETP is found in plasma, where it function in the transfer of cholesteryl ester from high density lipoprotein (HDL) to other lipoproteins. Defects in this gene are a cause of hyperalphalipoproteinemia 1 (HALP1). Two transcript variants encoding different isoforms have been observed for this gene.
Entrez Gene ID
1071
UniProt ID
P11597
Alternative Names
Cholesteryl Ester Transfer Protein; BPI Fold Containing Family F; Lipid Transfer Protein I; Cholesteryl Ester Transfer Protein, Plasma; Cholesteryl Ester Transfer Protein Plasma; HDLCQ10; BPIFF
Function
Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL (PubMed:3600759, PubMed:24293641, PubMed:3281933).
Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (PubMed:17237796).
Biological Process
Cholesterol homeostasis Source: BHF-UCL
Cholesterol metabolic process Source: BHF-UCL
Cholesterol transport Source: UniProtKB
High-density lipoprotein particle remodeling Source: UniProtKB
Intracellular receptor signaling pathway Source: Reactome
Lipid homeostasis Source: BHF-UCL
Lipid transport Source: BHF-UCL
Low-density lipoprotein particle remodeling Source: BHF-UCL
Negative regulation of macrophage derived foam cell differentiation Source: BHF-UCL
Phosphatidylcholine metabolic process Source: BHF-UCL
Phospholipid homeostasis Source: BHF-UCL
Positive regulation of cholesterol transport Source: BHF-UCL
Positive regulation of phospholipid transport Source: BHF-UCL
Regulation of cholesterol efflux Source: BHF-UCL
Reverse cholesterol transport Source: BHF-UCL
Triglyceride homeostasis Source: BHF-UCL
Triglyceride metabolic process Source: BHF-UCL
Triglyceride transport Source: UniProtKB
Very-low-density lipoprotein particle remodeling Source: UniProtKB
Cellular Location
Secreted. Secreted in plasma.
Involvement in disease
Hyperalphalipoproteinemia 1 (HALP1): A condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels.

Schmidt, A. F., Hunt, N. B., Gordillo-Marañón, M., Charoen, P., Drenos, F., Kivimaki, M., ... & Finan, C. (2021). Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease. Nature communications, 12(1), 1-10.

Vachal, P., Duffy, J. L., Campeau, L. C., Amin, R. P., Mitra, K., Murphy, B. A., ... & Johns, D. G. (2021). Invention of MK-8262, a Cholesteryl Ester Transfer Protein (CETP) Inhibitor Backup to Anacetrapib with Best-in-Class Properties. Journal of Medicinal Chemistry, 64(18), 13215-13258.

Armitage, J., Holmes, M. V., & Preiss, D. (2019). Cholesteryl ester transfer protein inhibition for preventing cardiovascular events: JACC review topic of the week. Journal of the American College of Cardiology, 73(4), 477-487.

Martinelli, A. E. M., Maranhão, R. C., Carvalho, P. O., Freitas, F. R., Silva, B. M., Curiati, M. N., ... & Pereira-Barretto, A. C. (2018). Cholesteryl ester transfer protein (CETP), HDL capacity of receiving cholesterol and status of inflammatory cytokines in patients with severe heart failure. Lipids in health and disease, 17(1), 1-9.

Blauw, L. L., Li-Gao, R., Noordam, R., de Mutsert, R., Trompet, S., Berbée, J. F., ... & Willems van Dijk, K. (2018). CETP (cholesteryl ester transfer protein) concentration: a genome-wide association study followed by Mendelian randomization on coronary artery disease. Circulation: Genomic and Precision Medicine, 11(5), e002034.

Masson, W., Lobo, M., Siniawski, D., Huerín, M., Molinero, G., Valero, R., & Nogueira, J. P. (2018). Therapy with cholesteryl ester transfer protein (CETP) inhibitors and diabetes risk. Diabetes & metabolism, 44(6), 508-513.

Thomas, T., Zhou, H., Karmally, W., Ramakrishnan, R., Holleran, S., Liu, Y., ... & Reyes-Soffer, G. (2017). CETP (cholesteryl ester transfer protein) inhibition with anacetrapib decreases production of lipoprotein (a) in mildly hypercholesterolemic subjects. Arteriosclerosis, thrombosis, and vascular biology, 37(9), 1770-1775.

Kurano, M., Hara, M., Ikeda, H., Tsukamoto, K., & Yatomi, Y. (2017). Involvement of CETP (cholesteryl ester transfer protein) in the shift of sphingosine-1-phosphate among lipoproteins and in the modulation of its functions. Arteriosclerosis, thrombosis, and vascular biology, 37(3), 506-514.

Nomura, A., Won, H. H., Khera, A. V., Takeuchi, F., Ito, K., McCarthy, S., ... & Kathiresan, S. (2017). Protein-truncating variants at the cholesteryl ester transfer protein gene and risk for coronary heart disease. Circulation research, 121(1), 81-88.

Liutkeviciene, R., Vilkeviciute, A., Streleckiene, G., Kriauciuniene, L., Chaleckis, R., & Deltuva, V. P. (2017). Associations of cholesteryl ester transfer protein (CETP) gene variants with predisposition to age-related macular degeneration. Gene, 636, 30-35.

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For research use only. Not intended for any clinical use.

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