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CHAF1A

Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B; MIM 601245), and p150 (CHAF1A) subunits that assembles histone octamers onto replicating DNA in vitro (Kaufman et al., 1995 [PubMed 7600578]).[supplied by OMIM, Mar 2008]

Full Name

Chromatin Assembly Factor 1 Subunit A

Function

Core component of the CAF-1 complex, a complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci.

Biological Process

Cell cycle Source: UniProtKB-KW
Chromatin assembly Source: UniProtKB
DNA repair Source: UniProtKB-KW
DNA replication Source: UniProtKB-KW
DNA replication-dependent nucleosome assembly Source: UniProtKB
Nucleosome assembly Source: GO_Central

Cellular Location

Nucleus. DNA replication foci.

Anti-CHAF1A antibodies

Rabbit Anti-CHAF1A Recombinant Antibody (CBWJC-2619) (CBMAB-C3704WJ)

SDS

Target: CHAF1A

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Monkey

Clone: CBWJC-2619

Application*: WB, IP, IF

Mouse Anti-CHAF1A Recombinant Antibody (2168C3a) (CBMAB-C0636-LY)

SDS

Target: CHAF1A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2168C3a

Application*: DB, WB

Mouse Anti-CHAF1A Recombinant Antibody (1SS-48) (CBMAB-P0226-YC)

SDS

Target: CHAF1A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1SS-48

Application*: WB, IP, IC, IF

Rabbit Anti-CHAF1A Recombinant Antibody (CBYC-P048) (CBMAB-P0227-YC)

SDS

Target: CHAF1A

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBYC-P048

Application*: F, IC, IF

Mouse Anti-CHAF1A Recombinant Antibody (3C125) (CBMAB-C2305-CN)

SDS

Target: CHAF1A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3C125

Application*: E

Mouse Anti-CHAF1A Recombinant Antibody (SS 1 1-13) (CBMAB-C10948-LY)

SDS

Target: CHAF1A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: SS 1 1-13

Application*: WB, IC/IF, IP

Rabbit Anti-CHAF1A Recombinant Antibody (D77D5) (CBMAB-CP0287-LY)

SDS

Target: CHAF1A

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Monkey

Clone: D77D5

Application*: WB, IP, IF (IC)

Rabbit Anti-CHAF1A Recombinant Antibody (EG461) (CBMAB-EN521-LY)

SDS

Target: CHAF1A

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: EG461

Application*: WB: 1:500~1:1000 ELISA: 1:10000

Rabbit Anti-CHAF1A Recombinant Antibody (CBFYC-1796) (CBMAB-C1858-FY)

SDS

Target: CHAF1A

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: CBFYC-1796

Application*: IF, IP, WB

Mouse Anti-CHAF1A (AA 21-120) Recombinant Antibody (CBFYC-1797) (CBMAB-C1859-FY)

SDS

Target: CHAF1A

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBFYC-1797

Application*: E, WB

Mouse Anti-CHAF1A Recombinant Antibody (CBFYC-1798) (CBMAB-C1860-FY)

SDS

Target: CHAF1A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-1798

Application*: DB

Mouse Anti-CHAF1A Recombinant Antibody (p150-48) (CBMAB-C5331-CQ)

SDS

Target: CHAF1A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: p150-48

Application*: IC, IH, WB

Mouse Anti-CHAF1A Recombinant Antibody (p60-24) (CBMAB-C5332-CQ)

SDS

Target: CHAF1A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: p60-24

Application*: IC, IP

Mouse Anti-CHAF1A Recombinant Antibody (SS 11-13) (CBMAB-C5333-CQ)

SDS

Target: CHAF1A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: SS 11-13

Application*: WB, IP, IF

Mouse Anti-CHAF1A Recombinant Antibody (CBXC-0410) (CBMAB-C5334-CQ)

SDS

Target: CHAF1A

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXC-0410

Application*: E, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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