CHRNA5

The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).[provided by RefSeq, Jun 2010]
Full Name
Cholinergic Receptor Nicotinic Alpha 5 Subunit
Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Biological Process
Behavioral response to nicotine Source: UniProtKB
Chemical synaptic transmission Source: GO_Central
Ion transmembrane transport Source: GO_Central
Nervous system process Source: GO_Central
Regulation of membrane potential Source: GO_Central
Regulation of synaptic vesicle exocytosis Source: Ensembl
Response to nicotine Source: GO_Central
Signal transduction Source: GO_Central
Synaptic transmission, cholinergic Source: GO_Central
Cellular Location
Postsynaptic cell membrane; Cell membrane
Topology
Extracellular: 23-254
Helical: 255-275
Helical: 282-302
Helical: 317-337
Cytoplasmic: 338-429
Helical: 430-451
Extracellular: 452-468
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Anti-CHRNA5 antibodies

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Mouse Anti-CHRNA5 Recombinant Antibody (7D3) (CBMAB-C8625-LY)

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Target: CHRNA5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 7D3
Application*: E, WB
Datasheet SDS

Rat Anti-CHRNA5 Recombinant Antibody (C6194) (CBMAB-C6194-LY)

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Target: CHRNA5
Host: Rat
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: C6194
Application*: WB, IP, F
Datasheet SDS

Mouse Anti-CHRNA5 Recombinant Antibody (CBT4210) (V2LY-0625-LY755)

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Target: CHRNA5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBT4210
Application*: WB, F
Datasheet SDS

Mouse Anti-CHRNA5 Recombinant Antibody (CBT2919) (V2LY-0625-LY754)

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Target: CHRNA5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Rat
Clone: CBT2919
Application*: WB, F
Datasheet SDS

Mouse Anti-CHRNA5 Recombinant Antibody (CBYY-C3166) (CBMAB-C4609-YY)

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Target: CHRNA5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Rat
Clone: CBYY-C3166
Application*: E, WB, F
Datasheet SDS

Mouse Anti-CHRNA5 Recombinant Antibody (BA0287) (CBMAB-0243CQ)

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Target: CHRNA5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: BA0287
Application*: E, IF, WB, IP, P
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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