CLDN2

This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.[provided by RefSeq, Jan 2010]
Full Name
Claudin 2
Function
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Biological Process
Bicellular tight junction assembly Source: GO_Central
Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
Cell adhesion Source: GO_Central
Cellular Location
Cell membrane; Tight junction
Topology
Cytoplasmic: 1-7
Helical: 8-28
Extracellular: 29-81
Helical: 82-102
Cytoplasmic: 103-116
Helical: 117-137
Extracellular: 138-162
Helical: 163-183
Cytoplasmic: 184-230
PTM
The disulfide bond is necessary for pore formation, but is not required for correct protein trafficking.
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Anti-CLDN2 antibodies

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Mouse Anti-CLDN2 Recombinant Antibody (3F1) (CBMAB-C1115-LY)

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Target: CLDN2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 3F1
Application*: E, WB, IP
Datasheet SDS

Mouse Anti-CLDN2 Recombinant Antibody (CBCNC-010) (V2LY-1206-LY27)

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Target: CLDN2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Cat, Dog, Human, Mouse, Pig, Rat, Monkey
Clone: CBCNC-010
Application*: E, IF, IP, WB, P, F
Datasheet SDS

Rabbit Anti-CLDN2 Recombinant Antibody (CBWJC-2764) (V2LY-1206-LY26)

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Target: CLDN2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Monkey
Clone: CBWJC-2764
Application*: WB, IP
Datasheet SDS

Mouse Anti-CLDN2 Recombinant Antibody (CBYY-C3151) (V2LY-1206-LY25)

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Target: CLDN2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYY-C3151
Application*: IH, WB
Datasheet SDS

Mouse Anti-CLDN2 Recombinant Antibody (CBFYC-1903) (V2LY-1206-LY24)

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Target: CLDN2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-1903
Application*: E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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