CLEC7A

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

C-Type Lectin Domain Containing 7A

Lectin that functions as pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi (PubMed:11567029, PubMed:12423684).

Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (By similarity).

Enhances cytokine production in macrophages and dendritic cells (By similarity).

Mediates production of reactive oxygen species in the cell (By similarity).

Mediates phagocytosis of C.albicans conidia (PubMed:17230442).

Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Induces phosphorylation of SCIMP after binding beta-glucans (By similarity).

Carbohydrate mediated signaling Source: UniProtKB
Cell recognition Source: UniProtKB
Cellular response to molecule of fungal origin Source: ARUK-UCL
Defense response to protozoan Source: UniProtKB
Detection of fungus Source: ARUK-UCL
Detection of molecule of fungal origin Source: ARUK-UCL
Inflammatory response Source: UniProtKB-KW
Innate immune response Source: UniProtKB-KW
Leukocyte activation involved in immune response Source: Ensembl
Phagocytosis, recognition Source: UniProtKB
Positive regulation of cell maturation Source: ARUK-UCL
Positive regulation of cell migration Source: ARUK-UCL
Positive regulation of cell population proliferation Source: ARUK-UCL
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: ARUK-UCL
Positive regulation of cytokine production involved in inflammatory response Source: ARUK-UCL
Positive regulation of dendritic cell cytokine production Source: Ensembl
Positive regulation of gene expression Source: ARUK-UCL
Positive regulation of interferon-gamma production Source: ARUK-UCL
Positive regulation of interleukin-10 production Source: ARUK-UCL
Positive regulation of interleukin-12 production Source: ARUK-UCL
Positive regulation of interleukin-1 beta production Source: ARUK-UCL
Positive regulation of interleukin-2 production Source: ARUK-UCL
Positive regulation of interleukin-6 production Source: ARUK-UCL
Positive regulation of interleukin-8 production Source: ARUK-UCL
Positive regulation of killing of cells of other organism Source: ARUK-UCL
Positive regulation of lymphocyte activation Source: ARUK-UCL
Positive regulation of monocyte chemotactic protein-1 production Source: ARUK-UCL
Positive regulation of nitric oxide biosynthetic process Source: ARUK-UCL
Positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
Positive regulation of phagocytosis Source: ARUK-UCL
Positive regulation of protein-containing complex assembly Source: ARUK-UCL
Positive regulation of respiratory burst Source: ARUK-UCL
Positive regulation of stress-activated MAPK cascade Source: Ensembl
Positive regulation of superoxide anion generation Source: ARUK-UCL
Positive regulation of tumor necrosis factor production Source: ARUK-UCL
Positive regulation of wound healing Source: ARUK-UCL
T cell activation Source: UniProtKB

Cell membrane
Isoform 5&6&7: Cytoplasm

Candidiasis, familial, 4 (CANDF4):
A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.

Cytoplasmic: 1-44
Helical: 45-65
Extracellular: 66-247

Phosphorylated on tyrosine residues in response to beta-glucan binding.