Human Recombinant CLEC7A protein, hFc Tag (V2LY-0526-LY3536)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (By similarity).
Enhances cytokine production in macrophages and dendritic cells (By similarity).
Mediates production of reactive oxygen species in the cell (By similarity).
Mediates phagocytosis of C.albicans conidia (PubMed:17230442).
Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Induces phosphorylation of SCIMP after binding beta-glucans (By similarity).
Cell recognition Source: UniProtKB
Cellular response to molecule of fungal origin Source: ARUK-UCL
Defense response to protozoan Source: UniProtKB
Detection of fungus Source: ARUK-UCL
Detection of molecule of fungal origin Source: ARUK-UCL
Inflammatory response Source: UniProtKB-KW
Innate immune response Source: UniProtKB-KW
Leukocyte activation involved in immune response Source: Ensembl
Phagocytosis, recognition Source: UniProtKB
Positive regulation of cell maturation Source: ARUK-UCL
Positive regulation of cell migration Source: ARUK-UCL
Positive regulation of cell population proliferation Source: ARUK-UCL
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: ARUK-UCL
Positive regulation of cytokine production involved in inflammatory response Source: ARUK-UCL
Positive regulation of dendritic cell cytokine production Source: Ensembl
Positive regulation of gene expression Source: ARUK-UCL
Positive regulation of interferon-gamma production Source: ARUK-UCL
Positive regulation of interleukin-10 production Source: ARUK-UCL
Positive regulation of interleukin-12 production Source: ARUK-UCL
Positive regulation of interleukin-1 beta production Source: ARUK-UCL
Positive regulation of interleukin-2 production Source: ARUK-UCL
Positive regulation of interleukin-6 production Source: ARUK-UCL
Positive regulation of interleukin-8 production Source: ARUK-UCL
Positive regulation of killing of cells of other organism Source: ARUK-UCL
Positive regulation of lymphocyte activation Source: ARUK-UCL
Positive regulation of monocyte chemotactic protein-1 production Source: ARUK-UCL
Positive regulation of nitric oxide biosynthetic process Source: ARUK-UCL
Positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
Positive regulation of phagocytosis Source: ARUK-UCL
Positive regulation of protein-containing complex assembly Source: ARUK-UCL
Positive regulation of respiratory burst Source: ARUK-UCL
Positive regulation of stress-activated MAPK cascade Source: Ensembl
Positive regulation of superoxide anion generation Source: ARUK-UCL
Positive regulation of tumor necrosis factor production Source: ARUK-UCL
Positive regulation of wound healing Source: ARUK-UCL
T cell activation Source: UniProtKB
Isoform 5&6&7: Cytoplasm
A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.
Helical: 45-65
Extracellular: 66-247
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Alternative Versions
Human Recombinant CLEC7A protein, Biotin Conjugated, hFc & AVI Tag (CAT#: V2LY-0526-LY3535)
Human Recombinant CLEC7A protein, Fc Tag (CAT#: V2LY-0526-LY3538)
Human Recombinant CLEC7A protein, Fc Tag-1 (CAT#: V2LY-0526-LY3539)
Human Recombinant CLEC7A protein (CAT#: V2LY-0526-LY3540)
Mouse Recombinant CLEC7A protein, His Tag (CAT#: V2LY-0526-LY8192)
Human CLEC7A ELISA Kit (CAT#: V2LY-0626-LY4041)
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Human CLEC7A ELISA Kit (CAT#: V2LY-0626-LY4041)
Mouse Recombinant CLEC7A protein, His Tag (CAT#: V2LY-0526-LY8192)
Human Recombinant CLEC7A protein, Fc Tag-1 (CAT#: V2LY-0526-LY3539)
Mouse Anti-CLEC7A Recombinant Antibody (CBXC-0469) (CAT#: V2LY-1206-LY190)
Rabbit Anti-CLEC7A Recombinant Antibody (CBYCD-534) (CAT#: V2LY-1206-LY186)
Rat Anti-CLEC7A Recombinant Antibody (CBYCD-535) (CAT#: V2LY-1206-LY187)
Mouse Anti-CLEC7A Recombinant Antibody (CBT2688) (CAT#: V2LY-0625-LY1218)
Human Recombinant CLEC7A protein, hFc Tag-1 (CAT#: V2LY-0526-LY3537)
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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