CLTA

Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
Full Name
clathrin, light chain (Lca)
Function
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:21297582).
Biological Process
Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Clathrin coat assembly Source: CAFA
Clathrin-dependent endocytosis Source: GO_Central
Intracellular protein transport Source: InterPro
Low-density lipoprotein particle clearance Source: Reactome
Low-density lipoprotein particle receptor catabolic process Source: Reactome
Membrane organization Source: Reactome
Post-Golgi vesicle-mediated transport Source: Reactome
Cellular Location
Spindle; Cytoplasmic vesicle membrane; Coated pit. Cytoplasmic face of coated pits and vesicles. In complex with TACC3 and CKAP5 (forming the TACC3/ch-TOG/clathrin complex) localized to inter-microtubule bridges in mitotic spindles.
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Anti-CLTA antibodies

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Mouse Anti-CLTA Recombinant Antibody (CBYY-C3188) (CBMAB-C4631-YY)

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Target: CLTA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYY-C3188
Application*: WB, F, IF, IH
Datasheet SDS

Mouse Anti-CLTA Recombinant Antibody (4D5) (CBMAB-C6792-LY)

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Target: CLTA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4D5
Application*: E, WB
Datasheet SDS

Mouse Anti-CLTA Recombinant Antibody (CBWJC-2823) (V2LY-1206-LY304)

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Target: CLTA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBWJC-2823
Application*: WB, IH
Datasheet SDS

Mouse Anti-CLTA Recombinant Antibody (CBXC-2551) (V2LY-1206-LY302)

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Target: CLTA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2551
Application*: WB, IH
Datasheet SDS

Mouse Anti-CLTA Recombinant Antibody (3F133) (V2LY-1206-LY299)

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Target: CLTA
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human, Mouse, Rat
Clone: 3F133
Application*: WB, IH
Datasheet SDS

Mouse Anti-CLTA Recombinant Antibody (4E9) (V2LY-1206-LY298)

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Target: CLTA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4E9
Application*: E, WB
Datasheet SDS

Mouse Anti-CLTA Recombinant Antibody (CBWJC-2046) (CBMAB-C2683WJ)

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Target: CLTA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBWJC-2046
Application*: WB, IH
Datasheet SDS

Mouse Anti-CLTA Recombinant Antibody (C0587) (CBMAB-C0587-CQ)

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Target: CLTA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: C0587
Application*: P
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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