CNIH3

CNIH3 (Cornichon Family AMPA Receptor Auxiliary Protein 3) is a Protein Coding gene. Diseases associated with CNIH3 include Schizophrenia. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include channel regulator activity. An important paralog of this gene is CNIH2.

Full Name

cornichon family AMPA receptor auxiliary protein 3

Function

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization.

Biological Process

COPII vesicle coating Source: Reactome
Endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
Regulation of AMPA receptor activity Source: UniProtKB
Regulation of membrane potential Source: Ensembl
Synaptic transmission, glutamatergic Source: Ensembl

Cellular Location

Postsynaptic cell membrane. Also localizes to the cell membrane of extrasynaptic sites (dendritic shafts, spines of pyramidal cells).

Topology

Cytoplasmic: 1-10
Helical: 11-31
Lumenal: 32-72
Helical: 73-93
Cytoplasmic: 94-138
Helical: 139-159
Lumenal: 160

Anti-CNIH3 antibodies

Mouse Anti-CNIH3 (AA 1-160) Recombinant Antibody (CBFYC-1985) (CBMAB-C2051-FY)

Datasheet

SDS

Target: CNIH3

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBFYC-1985

Application*: E

Mouse Anti-CNIH3 Recombinant Antibody (1E10) (CBMAB-C3904-LY)

Datasheet

SDS

Target: CNIH3

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 1E10

Application*: E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)