CNIH3

CNIH3 (Cornichon Family AMPA Receptor Auxiliary Protein 3) is a Protein Coding gene. Diseases associated with CNIH3 include Schizophrenia. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include channel regulator activity. An important paralog of this gene is CNIH2.

Full Name

cornichon family AMPA receptor auxiliary protein 3

Function

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization.

Biological Process

COPII vesicle coating Source: Reactome
Endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
Regulation of AMPA receptor activity Source: UniProtKB
Regulation of membrane potential Source: Ensembl
Synaptic transmission, glutamatergic Source: Ensembl

Cellular Location

Postsynaptic cell membrane. Also localizes to the cell membrane of extrasynaptic sites (dendritic shafts, spines of pyramidal cells).

Topology

Cytoplasmic: 1-10
Helical: 11-31
Lumenal: 32-72
Helical: 73-93
Cytoplasmic: 94-138
Helical: 139-159
Lumenal: 160