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Mouse Anti-CNIH3 Recombinant Antibody (1E10) (CBMAB-C3904-LY)

This product is antibody recognizes CNIH3. The antibody 1E10 immunoassay techniques such as: ELISA.
See all CNIH3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1E10
Antibody Isotype
IgG2b, κ
Application
ELISA

Basic Information

Immunogen
CNIH3 (AAH22780, 1 a.a. ~ 160 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: MAFTFAAFCY MLSLVLCAAL IFFAIWHIIA FDELRTDFKS PIDQCNPVHA RERLRNIERI CFLLRKLVLP EYSIHSLFCI MFLCAQEWLT LGLNVPLLFY HFWRYFHCPA
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
cornichon family AMPA receptor auxiliary protein 3
Introduction
CNIH3 (Cornichon Family AMPA Receptor Auxiliary Protein 3) is a Protein Coding gene. Diseases associated with CNIH3 include Schizophrenia. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include channel regulator activity. An important paralog of this gene is CNIH2.
Entrez Gene ID
149111
UniProt ID
Q8TBE1
Alternative Names
Cornichon Family AMPA Receptor Auxiliary Protein 3; CNIH-3; Cornichon Homolog 3 (Drosophila); Protein Cornichon Homolog 3; Cornichon Homolog 3;
Function
Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization.
Biological Process
COPII vesicle coating Source: Reactome
Endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
Regulation of AMPA receptor activity Source: UniProtKB
Regulation of membrane potential Source: Ensembl
Synaptic transmission, glutamatergic Source: Ensembl
Cellular Location
Postsynaptic cell membrane. Also localizes to the cell membrane of extrasynaptic sites (dendritic shafts, spines of pyramidal cells).
Topology
Cytoplasmic: 1-10
Helical: 11-31
Lumenal: 32-72
Helical: 73-93
Cytoplasmic: 94-138
Helical: 139-159
Lumenal: 160
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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