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Mouse Anti-CNIH3 Recombinant Antibody (1E10) (CBMAB-C3904-LY)

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Datasheet
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Basic Information

Host Animal
Mouse
Clone
1E10
Application
ELISA
Immunogen
Full length recombinant CNIH3.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
cornichon family AMPA receptor auxiliary protein 3
Introduction
CNIH3 (Cornichon Family AMPA Receptor Auxiliary Protein 3) is a Protein Coding gene. Diseases associated with CNIH3 include Schizophrenia. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include channel regulator activity. An important paralog of this gene is CNIH2.
Entrez Gene ID
149111
UniProt ID
Q8TBE1
Alternative Names
Cornichon Family AMPA Receptor Auxiliary Protein 3; CNIH-3; Cornichon Homolog 3 (Drosophila); Protein Cornichon Homolog 3; Cornichon Homolog 3;
Function
Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization.
Biological Process
COPII vesicle coating Source: Reactome
Endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
Regulation of AMPA receptor activity Source: UniProtKB
Regulation of membrane potential Source: Ensembl
Synaptic transmission, glutamatergic Source: Ensembl
Cellular Location
Postsynaptic cell membrane. Also localizes to the cell membrane of extrasynaptic sites (dendritic shafts, spines of pyramidal cells).
Topology
Cytoplasmic: 1-10
Helical: 11-31
Lumenal: 32-72
Helical: 73-93
Cytoplasmic: 94-138
Helical: 139-159
Lumenal: 160

Ramos-Vicente, D., & Bayés, À. (2020). AMPA receptor auxiliary subunits emerged during early vertebrate evolution by neo/subfunctionalization of unrelated proteins. Open biology, 10(10), 200234.

von Engelhardt, J. (2019). AMPA receptor auxiliary proteins of the CKAMP family. International journal of molecular sciences, 20(6), 1460.

Jacobi, E., & von Engelhardt, J. (2018). AMPA receptor complex constituents: Control of receptor assembly, membrane trafficking and subcellular localization. Molecular and Cellular Neuroscience, 91, 67-75.

Brown, P. M., McGuire, H., & Bowie, D. (2018). Stargazin and cornichon-3 relieve polyamine block of AMPA receptors by enhancing blocker permeation. Journal of General Physiology, 150(1), 67-82.

Hawken, N. M., Zaika, E. I., & Nakagawa, T. (2017). Engineering defined membrane‐embedded elements of AMPA receptor induces opposing gating modulation by cornichon 3 and stargazin. The Journal of Physiology, 595(20), 6517-6539.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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