CPB2

CPB2 (Carboxypeptidase B2) is a Protein Coding gene. Diseases associated with CPB2 include Factor Xiii Deficiency and Factor Xi Deficiency. Among its related pathways are Peptide hormone metabolism and Complement and coagulation cascades. Gene Ontology (GO) annotations related to this gene include metallocarboxypeptidase activity and carboxypeptidase activity. An important paralog of this gene is CPB1.

Carboxypeptidase B2

Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.

Blood coagulation Source: UniProtKB-KW
Cellular response to glucose stimulus Source: Ensembl
Fibrinolysis Source: GO_Central
Liver regeneration Source: Ensembl
Negative regulation of fibrinolysis Source: Ensembl
Negative regulation of hepatocyte proliferation Source: Ensembl
Negative regulation of plasminogen activation Source: Ensembl
Positive regulation of extracellular matrix constituent secretion Source: Ensembl
Proteolysis Source: GO_Central
Regulation of complement activation Source: Reactome
Response to drug Source: Ensembl
Response to heat Source: Ensembl

Secreted

N-glycosylated. N-glycan at Asn-108: Hex5HexNAc4.