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Rabbit Anti-CPB2 Recombinant Antibody (173) (V2LY-1206-LY933)


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Summary

Host Animal
Rabbit
Specificity
Mouse
Clone
173
Antibody Isotype
IgG
Application
ELISA

Basic Information

Immunogen
Recombinant Mouse Carboxypeptidase B2 / CPB2 protein.
Host Species
Rabbit
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
ELISA1:5,000-1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Carboxypeptidase B2
Entrez Gene ID
56373
UniProt ID
Q9JHH6
Function
Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.
Biological Process
Blood coagulation Source: UniProtKB-KW
Cellular response to glucose stimulus Source: Ensembl
Fibrinolysis Source: GO_Central
Liver regeneration Source: Ensembl
Negative regulation of fibrinolysis Source: Ensembl
Negative regulation of hepatocyte proliferation Source: Ensembl
Negative regulation of plasminogen activation Source: Ensembl
Positive regulation of extracellular matrix constituent secretion Source: Ensembl
Proteolysis Source: GO_Central
Regulation of complement activation Source: Reactome
Response to drug Source: Ensembl
Response to heat Source: Ensembl
Cellular Location
Secreted
PTM
N-glycosylated. N-glycan at Asn-108: Hex5HexNAc4.
More Infomation

Zhou, Q., Zhao, L., Shao, Z., Declerck, P., Leung, L. L., & Morser, J. (2022). Both plasma basic carboxypeptidases, carboxypeptidase B2 and carboxypeptidase N, regulate vascular leakage activity in mice. Journal of Thrombosis and Haemostasis, 20(1), 238-244.

Claesen, K., Mertens, J. C., Basir, S., De Belder, S., Maes, J., Bosmans, J., ... & Hendriks, D. (2021). Effect of Statin Therapy on the Carboxypeptidase U (CPU, TAFIa, CPB2) System in Patients With Hyperlipidemia: A Proof-of-Concept Observational Study. Clinical Therapeutics, 43(5), 908-916.

Claesen, K., Mertens, J. C., Leenaerts, D., & Hendriks, D. (2021). Carboxypeptidase U (CPU, TAFIa, CPB2) in thromboembolic disease: what do we know three decades after its discovery?. International journal of molecular sciences, 22(2), 883.

Claesen, K., Roth, L., Mertens, J. C., Hermans, K., Sim, Y., & Hendriks, D. (2021). Pleiotropic Effects of Atorvastatin Result in a Downregulation of the Carboxypeptidase U System (CPU, TAFIa, CPB2) in a Mouse Model of Advanced Atherosclerosis. Pharmaceutics, 13(10), 1731.

Khamsehnejad, M. I., Djadid, N. D., & Raz, A. (2019). Identification, molecular characterization, and in silico structural analysis of carboxypeptidase B2 of Anopheles stephensi. Journal of Medical Entomology, 56(1), 72-85.

Leenaerts, D., Loyau, S., Mertens, J. C., Boisseau, W., Michel, J. B., Lambeir, A. M., ... & Hendriks, D. (2018). Carboxypeptidase U (CPU, carboxypeptidase B2, activated thrombin‐activatable fibrinolysis inhibitor) inhibition stimulates the fibrinolytic rate in different in vitro models. Journal of Thrombosis and Haemostasis, 16(10), 2057-2069.

Leung, L. L. K., & Morser, J. (2018). Carboxypeptidase B2 and carboxypeptidase N in the crosstalk between coagulation, thrombosis, inflammation, and innate immunity. Journal of Thrombosis and Haemostasis, 16(8), 1474-1486.

Morser, J., Shao, Z., Nishimura, T., Zhou, Q., Zhao, L., Higgins, J., & Leung, L. L. K. (2018). Carboxypeptidase B2 and N play different roles in regulation of activated complements C3a and C5a in mice. Journal of Thrombosis and Haemostasis, 16(5), 991-1002.

Mohamed, H. T., El-Husseiny, N., El-Ghonaimy, E. A., Ibrahim, S. A., Bazzi, Z. A., Cavallo-Medved, D., ... & Mohamed, M. M. (2018). IL-10 correlates with the expression of carboxypeptidase B2 and lymphovascular invasion in inflammatory breast cancer: the potential role of tumor infiltrated macrophages. Current Problems in Cancer, 42(2), 215-230.

Oguntona, T. S. (2018). The potential role of a carboxypeptidase B2 inhibitor in renal fibrosis (Doctoral dissertation, University of Sheffield).

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For research use only. Not intended for any clinical use.

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