CPLX4

CPLX4 (Complexin 4) is a Protein Coding gene. Among its related pathways are Synaptic vesicle cycle. Gene Ontology (GO) annotations related to this gene include syntaxin binding and SNARE binding. An important paralog of this gene is CPLX3.

Full Name

Complexin 4

Function

Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (By similarity).

Required for the maintenance of synaptic ultrastructure in the adult retina (By similarity).

Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (By similarity).

Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca2+ vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca2+ vesicle release (By similarity).

Biological Process

Regulation of neurotransmitter secretion Source: GO_Central
Response to stimulus Source: UniProtKB-KW
Synaptic vesicle exocytosis Source: GO_Central
Visual perception Source: UniProtKB-KW

Cellular Location

Cell membrane; Synapse. Enriched at the synaptic terminal.

PTM

Farnesylation mediates presynaptic targeting and is important for function in neurotransmitter release.