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Mouse Anti-CPLX4 Recombinant Antibody (171H8) (V2LY-1206-LY960)


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Published Data
V2LY-1206-LY960-1
Mouse Anti-CPLX4 Recombinant Antibody (171H8) (V2LY-1206-LY960) in PLA
Spatial proximity of Cplx4 and Gt in light at rod photoreceptor ribbon synapses in vivo. Fluorescence micrographs of in situ proximity ligation assays (PLA) performed on vertical cryostat sections with antibodies against Gαt1 and Cplx4 (A,B) and Gγ1 and Cplx4 (A',B') after dark adaptation (A,A') and light adaptation (B,B'). ...View More
Lux, U. T., Meyer, J., Jahn, O., Davison, A., Babai, N., Gieβl, A., ... & Brandstätter, J. H. (2024). Light-dependent regulation of neurotransmitter release from rod photoreceptor ribbon synapses involves an interplay of Complexin 4 and Transducin with the SNARE complex. Frontiers in Molecular Neuroscience, 17, 1308466.
Distributed under Open Access license CC BY 4.0, without modification.
V2LY-1206-LY960-2
Mouse Anti-CPLX4 Recombinant Antibody (171H8) (V2LY-1206-LY960) in PLA
The spatial association of Gt and the SNARE complex at rod ribbon synapses is independent of Cplx4. Fluorescence micrographs of in situ proximity ligation assays (PLA) performed on vertical cryostat sections of Cplx4 WT (A,B) and Cplx4 KO mice (C,D) with antibodies against Gαt1 (magenta) and VAMP2 (green) after dark adaptation (A,C) and light adaptation (B,D). ...View More
Lux, U. T., Meyer, J., Jahn, O., Davison, A., Babai, N., Gieβl, A., ... & Brandstätter, J. H. (2024). Light-dependent regulation of neurotransmitter release from rod photoreceptor ribbon synapses involves an interplay of Complexin 4 and Transducin with the SNARE complex. Frontiers in Molecular Neuroscience, 17, 1308466.
Distributed under Open Access license CC BY 4.0, without modification.

Summary

Host Animal
Mouse
Specificity
Rat, Mouse
Clone
171H8
Antibody Isotype
IgG1, κ
Application
IHC, WB, IF, IP

Basic Information

Immunogen
Recombinant protein corresponding to aa1-160 from mouse Complexin4.
Host Species
Mouse
Specificity
Rat, Mouse
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:1,000
IHC1:1,000-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID
Mouse225644
Rat361342
UniProt ID
MouseQ80WM3
RatD3ZM85
Function
Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (By similarity).

Required for the maintenance of synaptic ultrastructure in the adult retina (By similarity).

Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (By similarity).

Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca2+ vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca2+ vesicle release (By similarity).
Biological Process
Regulation of neurotransmitter secretion Source: GO_Central
Response to stimulus Source: UniProtKB-KW
Synaptic vesicle exocytosis Source: GO_Central
Visual perception Source: UniProtKB-KW
Cellular Location
Cell membrane; Synapse. Enriched at the synaptic terminal.
PTM
Farnesylation mediates presynaptic targeting and is important for function in neurotransmitter release.
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For research use only. Not intended for any clinical use.

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