CPNE1

CPNE1 (Copine 1) is a Protein Coding gene. Among its related pathways are Innate Immune System and Metabolism. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calcium-dependent phospholipid binding. An important paralog of this gene is CPNE3.

Full Name

Copine 1

Function

Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes (PubMed:14674885).

Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner (PubMed:14674885).

Exhibits calcium-dependent phospholipid binding properties (PubMed:9430674, PubMed:19539605).

Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner (PubMed:23263657, PubMed:25450385).

May recruit target proteins to the cell membrane in a calcium-dependent manner (PubMed:12522145).

May function in membrane trafficking (PubMed:9430674).

Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit (PubMed:18212740).

Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL (PubMed:18212740).

Biological Process

Cellular response to calcium ion Source: UniProtKB
Glycerophospholipid biosynthetic process Source: Reactome
Lipid metabolic process Source: ProtInc
Negative regulation of DNA binding Source: UniProtKB
Negative regulation of gene expression Source: UniProtKB
Negative regulation of NIK/NF-kappaB signaling Source: UniProtKB
Neuron projection extension Source: UniProtKB
Neutrophil degranulation Source: Reactome
Positive regulation of neuron differentiation Source: UniProtKB
Positive regulation of protein kinase B signaling Source: UniProtKB
Positive regulation of tumor necrosis factor-mediated signaling pathway Source: UniProtKB
Proteolysis Source: UniProtKB
Regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Vesicle-mediated transport Source: ProtInc

Cellular Location

Nucleus; Cell membrane; Cytoplasm. Translocates to the cell membrane in a calcium-dependent manner (PubMed:21087455, PubMed:25450385).