CRHR1

CRHR1 (Corticotropin Releasing Hormone Receptor 1) is a Protein Coding gene. Diseases associated with CRHR1 include Irritable Bowel Syndrome and Anxiety. Among its related pathways are Peptide ligand-binding receptors and Presynaptic function of Kainate receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and protein complex binding. An important paralog of this gene is CRHR2.

Corticotropin Releasing Hormone Receptor 1

G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.

Activation of adenylate cyclase activity Source: ProtInc
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
Adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: GO_Central
Cell surface receptor signaling pathway Source: InterPro
Cellular response to corticotropin-releasing hormone stimulus Source: UniProtKB
Corticotropin secretion Source: UniProtKB
Female pregnancy Source: ProtInc
G protein-coupled receptor signaling pathway Source: Reactome
Immune response Source: ProtInc
Negative regulation of inflammatory response to antigenic stimulus Source: Reactome
Negative regulation of voltage-gated calcium channel activity Source: UniProtKB
Parturition Source: ProtInc
Regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway Source: UniProtKB
Regulation of corticosterone secretion Source: UniProtKB

Endosome; Cell membrane. Agonist-binding promotes endocytosis.

Extracellular: 24-111
Helical: 112-142
Cytoplasmic: 143-178
Helical: 179-203
Extracellular: 204-218
Helical: 219-247
Cytoplasmic: 248-254
Helical: 255-282
Extracellular: 283-298
Helical: 299-324
Cytoplasmic: 325-335
Helical: 336-360
Extracellular: 361-367
Helical: 368-397
Cytoplasmic: 398-444

C-terminal Ser or Thr residues may be phosphorylated.
Phosphorylation at Ser-330 by PKA prevents maximal coupling to Gq-protein, and thereby negatively regulates downstream signaling.