CTNNBL1
The protein encoded by this gene is a component of the pre-mRNA-processing factor 19-cell division cycle 5-like (PRP19-CDC5L) protein complex, which activates pre-mRNA splicing and is an integral part of the spliceosome. The encoded protein is also a nuclear localization sequence binding protein, and binds to activation-induced deaminase and is important for antibody diversification. This gene may also be associated with the development of obesity. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome.
Full Name
CTNNBL1
Function
Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.
Biological Process
Apoptotic process Source: UniProtKB-KW
mRNA splicing, via spliceosome Source: Reactome
Positive regulation of apoptotic process Source: UniProtKB
Somatic diversification of immunoglobulins Source: UniProtKB
mRNA splicing, via spliceosome Source: Reactome
Positive regulation of apoptotic process Source: UniProtKB
Somatic diversification of immunoglobulins Source: UniProtKB
Cellular Location
Isoform 1: Nucleus
Isoform 2: Cytoplasm
Isoform 2: Cytoplasm
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Anti-CTNNBL1 antibodies
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Target: CTNNBL1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: C7532
Application*: E, F, WB
Target: CTNNBL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1E4F5
Application*: WB, P, IF, E, F
Target: CTNNBL1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT3761
Application*: F
Target: CTNNBL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4520
Application*: WB, IH, IC, F
Target: CTNNBL1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT3665
Application*: WB, IH, IC, F
Target: CTNNBL1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Dog
Clone: CBFYC-2413
Application*: WB, IP, IF, E
Target: CTNNBL1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: C5244
Application*: WB, P, IF, E, F
Target: CTNNBL1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Dog
Clone: C0672
Application*: WB, IP, IF, E
Target: CTNNBL1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat, Dog
Clone: 1103CQ
Application*: WB, IP, IF, E
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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