Mouse Anti-CTNNBL1 Recombinant Antibody (C5244) (V2LY-0125-LY334)

Name: Mouse Anti-CTNNBL1 Recombinant Antibody (C5244)
SKU: V2LY-0125-LY334
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

C5244

Antibody Isotype

IgG2a

Application

WB, IHC-P, IF, ELISA, FC

Basic Information

Immunogen

Purified recombinant fragment of human CTNNBL1 (aa390-557) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal Antibody

Application Notes

Application	Note
IF(ICC)	1:50-1:200
ELISA	1:10,000
WB	1:500-1:2,000
FC	1:200-1:400
IHC-P	1:200-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium Azide

Concentration

1 mg/mL

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

CTNNBL1

Entrez Gene ID

56259

UniProt ID

Q8WYA6

Function

Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.

Biological Process

Apoptotic process Source: UniProtKB-KW
mRNA splicing, via spliceosome Source: Reactome
Positive regulation of apoptotic process Source: UniProtKB
Somatic diversification of immunoglobulins Source: UniProtKB

Cellular Location

Isoform 1: Nucleus
Isoform 2: Cytoplasm

More Infomation

References

Kuhny, M., Forbes, L. R., Çakan, E., Vega-Loza, A., Kostiuk, V., Dinesh, R. K., ... & Meffre, E. (2020). Disease-associated CTNNBL1 mutation impairs somatic hypermutation by decreasing nuclear AID. The Journal of clinical investigation, 130(8), 4411-4422.

Li, X., & Liu, S. (2019). Spliceosome-associated factor catenin b-like 1 accelerates ovarian cancer progression by inducing expression and nuclear accumulation of yes-associated protein. Int J Clin Exp Med, 12(1), 316-326.

Dong, B., Dai, G., Xu, L., & Shi, D. (2017). Detection of RACK1 and CTNNBL1‑induced activation of mouse splenocytes using an immunoprecipitation‑based technique. Molecular Medicine Reports, 16(5), 7056-7063.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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