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DECR1

This gene encodes an accessory enzyme which participates in the beta-oxidation and metabolism of unsaturated fatty enoyl-CoA esters. [provided by RefSeq]
Full Name
2,4-dienoyl CoA reductase 1, mitochondrial
Function
Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in mitochondria. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA.
Biological Process
Fatty acid beta-oxidation Source: UniProtKB
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Cellular Location
Mitochondrion
Involvement in disease
2,4-dienoyl-CoA reductase deficiency (DECRD):
The protein represented in this entry is involved in disease pathogenesis. A selective decrease in mitochondrial NADP(H) levels due to NADK2 mutations causes a deficiency of NADPH-dependent mitochondrial enzymes, such as DECR1 and AASS. A rare, autosomal recessive, inborn error of polyunsaturated fatty acids and lysine metabolism, resulting in mitochondrial dysfunction. Affected individuals have a severe encephalopathy with neurologic and metabolic abnormalities beginning in early infancy. Laboratory studies show increased C10:2 carnitine levels and hyperlysinemia.
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Anti-DECR1 antibodies

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Mouse Anti-DECR1 Recombinant Antibody (10B2703) (CBMAB-D0652-YC)

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Target: DECR1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 10B2703
Application*: E, WB
Datasheet SDS

Mouse Anti-DECR1 Recombinant Antibody (8B1AD10) (CBMAB-D0650-YC)

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Target: DECR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8B1AD10
Application*: E, IC, IH, IP
Datasheet SDS

Mouse Anti-DECR1 Recombinant Antibody (3D4) (CBMAB-D0648-YC)

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Target: DECR1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3D4
Application*: E, P, WB
Datasheet SDS

Mouse Anti-DECR1 Recombinant Antibody (3B2) (CBMAB-D0647-YC)

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Target: DECR1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3B2
Application*: WB, F, E, IC, IF
Datasheet SDS

Mouse Anti-DECR1 Recombinant Antibody (16C2) (CBMAB-D0646-YC)

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Target: DECR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 16C2
Application*: WB
Datasheet SDS

Mouse Anti-DECR1 Recombinant Antibody (10A11) (CBMAB-D0645-YC)

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Target: DECR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10A11
Application*: WB, IH
Datasheet SDS

Mouse Anti-DECR1 Recombinant Antibody (D0652) (V2LY-0425-LY138)

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Target: DECR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: D0652
Application*: WB, IH
Datasheet SDS

Mouse Anti-DECR1 Recombinant Antibody (D0650) (V2LY-0425-LY137)

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Target: DECR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: D0650
Application*: E, IF, IH, IP
Datasheet SDS

Mouse Anti-DECR1 Recombinant Antibody (3D4) (V2LY-0425-LY136)

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Target: DECR1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3D4
Application*: E, P, WB
Datasheet SDS

Mouse Anti-DECR1 Recombinant Antibody (3B2) (V2LY-0425-LY135)

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Target: DECR1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3B2
Application*: WB, F, E, IF
Datasheet SDS

Mouse Anti-DECR1 Recombinant Antibody (16C2) (V2LY-0425-LY134)

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Target: DECR1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Horse, Dog, Cattle, Pig, Chicken
Clone: 16C2
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-DECR1 Recombinant Antibody (10A11) (V2LY-0425-LY133)

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Target: DECR1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 10A11
Application*: WB, IP
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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