DECR1
This gene encodes an accessory enzyme which participates in the beta-oxidation and metabolism of unsaturated fatty enoyl-CoA esters. [provided by RefSeq]
Full Name
2,4-dienoyl CoA reductase 1, mitochondrial
Function
Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in mitochondria. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA.
Biological Process
Fatty acid beta-oxidation Source: UniProtKB
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Cellular Location
Mitochondrion
Involvement in disease
2,4-dienoyl-CoA reductase deficiency (DECRD):
The protein represented in this entry is involved in disease pathogenesis. A selective decrease in mitochondrial NADP(H) levels due to NADK2 mutations causes a deficiency of NADPH-dependent mitochondrial enzymes, such as DECR1 and AASS. A rare, autosomal recessive, inborn error of polyunsaturated fatty acids and lysine metabolism, resulting in mitochondrial dysfunction. Affected individuals have a severe encephalopathy with neurologic and metabolic abnormalities beginning in early infancy. Laboratory studies show increased C10:2 carnitine levels and hyperlysinemia.
The protein represented in this entry is involved in disease pathogenesis. A selective decrease in mitochondrial NADP(H) levels due to NADK2 mutations causes a deficiency of NADPH-dependent mitochondrial enzymes, such as DECR1 and AASS. A rare, autosomal recessive, inborn error of polyunsaturated fatty acids and lysine metabolism, resulting in mitochondrial dysfunction. Affected individuals have a severe encephalopathy with neurologic and metabolic abnormalities beginning in early infancy. Laboratory studies show increased C10:2 carnitine levels and hyperlysinemia.
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Anti-DECR1 antibodies
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CompareTarget: DECR1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 10B2703
Application*: E, WB
Target: DECR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8B1AD10
Application*: E, IC, IH, IP
Target: DECR1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3D4
Application*: E, P, WB
Target: DECR1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3B2
Application*: WB, F, E, IC, IF
Target: DECR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 16C2
Application*: WB
Target: DECR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10A11
Application*: WB, IH
Target: DECR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: D0652
Application*: WB, IH
Target: DECR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: D0650
Application*: E, IF, IH, IP
Target: DECR1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3D4
Application*: E, P, WB
Target: DECR1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3B2
Application*: WB, F, E, IF
Target: DECR1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Horse, Dog, Cattle, Pig, Chicken
Clone: 16C2
Application*: WB, IP, IF, E, P
Target: DECR1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 10A11
Application*: WB, IP
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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