Mouse Anti-DECR1 Recombinant Antibody (10A11) (CBMAB-D0645-YC)

Name: Mouse Anti-DECR1 Recombinant Antibody (10A11)
SKU: CBMAB-D0645-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

10A11

Application

WB, IHC

Immunogen

Full length human recombinant protein of human DECR1 (NP_001350) produced in HEK293T cell

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

2,4-dienoyl CoA reductase 1, mitochondrial

Introduction

DECR1 is an accessory enzyme which participates in the beta-oxidation and metabolism of unsaturated fatty enoyl-CoA esters.

Entrez Gene ID

1666

UniProt ID

Q16698

Alternative Names

2,4-Dienoyl-CoA Reductase 1; Short Chain Dehydrogenase/Reductase Family 18C Member 1; 2,4-Dienoyl-CoA Reductase 1, Mitochondrial; SDR18C1; DECR; Short Chain Dehydrogenase/Reductase Family 18C, Member 1; 2,4-Dienoyl-CoA Reductase, Mitochondrial;

Function

Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in mitochondria. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA.

Biological Process

Fatty acid beta-oxidation Source: UniProtKB
Positive regulation of cold-induced thermogenesis Source: YuBioLab

Cellular Location

Mitochondrion

Involvement in disease

2,4-dienoyl-CoA reductase deficiency (DECRD):
The protein represented in this entry is involved in disease pathogenesis. A selective decrease in mitochondrial NADP(H) levels due to NADK2 mutations causes a deficiency of NADPH-dependent mitochondrial enzymes, such as DECR1 and AASS. A rare, autosomal recessive, inborn error of polyunsaturated fatty acids and lysine metabolism, resulting in mitochondrial dysfunction. Affected individuals have a severe encephalopathy with neurologic and metabolic abnormalities beginning in early infancy. Laboratory studies show increased C10:2 carnitine levels and hyperlysinemia.

Zhou, H., Yan, Z., Qu, M., Zhang, G., Han, J., Wang, F., ... & Yang, X. (2022). DECR1 directly activates HSL to promote lipolysis in cervical cancer cells. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 1867(3), 159090.

Blomme, A., Ford, C. A., Mui, E., Patel, R., Ntala, C., Jamieson, L. E., ... & Leung, H. Y. (2020). 2, 4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer. Nature communications, 11(1), 1-17.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Alternative Versions

Mouse Anti-DECR1 Recombinant Antibody (10A11) (CAT#: V2LY-0425-LY133)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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