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Mouse Anti-DECR1 Recombinant Antibody (10A11) (CBMAB-D0645-YC)

Provided herein is a Mouse monoclonal antibody, which binds to 2,4-Dienoyl-CoA Reductase 1 (DECR1). The antibody can be used for immunoassay techniques, such as WB, IHC.
See all DECR1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
10A11
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Immunogen
Full length human recombinant protein of human DECR1 (NP_001350) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
2,4-dienoyl CoA reductase 1, mitochondrial
Introduction
DECR1 is an accessory enzyme which participates in the beta-oxidation and metabolism of unsaturated fatty enoyl-CoA esters.
Entrez Gene ID
1666
UniProt ID
Q16698
Alternative Names
2,4-Dienoyl-CoA Reductase 1; Short Chain Dehydrogenase/Reductase Family 18C Member 1; 2,4-Dienoyl-CoA Reductase 1, Mitochondrial; SDR18C1; DECR; Short Chain Dehydrogenase/Reductase Family 18C, Member 1; 2,4-Dienoyl-CoA Reductase, Mitochondrial;
Function
Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in mitochondria. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA.
Biological Process
Fatty acid beta-oxidation Source: UniProtKB
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Cellular Location
Mitochondrion
Involvement in disease
2,4-dienoyl-CoA reductase deficiency (DECRD):
The protein represented in this entry is involved in disease pathogenesis. A selective decrease in mitochondrial NADP(H) levels due to NADK2 mutations causes a deficiency of NADPH-dependent mitochondrial enzymes, such as DECR1 and AASS. A rare, autosomal recessive, inborn error of polyunsaturated fatty acids and lysine metabolism, resulting in mitochondrial dysfunction. Affected individuals have a severe encephalopathy with neurologic and metabolic abnormalities beginning in early infancy. Laboratory studies show increased C10:2 carnitine levels and hyperlysinemia.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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