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DENR

This gene encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. This gene was also shown to have increased expression in cells overexpressing HER-2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF-2 and the initiator tRNA-Met, directs the ribosome to the proper translation start site. Proteins similar to SUI have been found in mammals, insects, and plants. [provided by RefSeq, Jul 2008]

Full Name

Density Regulated Re-Initiation And Release Factor

Function

May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1.

Biological Process

Formation of translation preinitiation complex Source: UniProtKB
IRES-dependent viral translational initiation Source: UniProtKB
Ribosome disassembly Source: UniProtKB
Translation reinitiation Source: GO_Central

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Anti-DENR antibodies

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Mouse Anti-DENR Recombinant Antibody (1H3) (CBMAB-D0704-YC)

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Target: DENR

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1H3

Application*: WB

Mouse Anti-DENR Recombinant Antibody (1542CT106.51.79) (CBMAB-D0703-YC)

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Target: DENR

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 1542CT106.51.79

Application*: WB, P, IC, IF, F

Mouse Anti-DENR Recombinant Antibody (CAP621) (V2LY-0425-LY180)

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Target: DENR

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CAP621

Application*: F, IF, IH, WB

Mouse Anti-DENR Recombinant Antibody (CBAb081) (V2LY-0425-LY179)

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Target: DENR

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse, Rat

Clone: CBAb081

Application*: E, WB

Mouse Anti-DENR Recombinant Antibody (D0704) (V2LY-0425-LY178)

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Target: DENR

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse, Rat

Clone: D0704

Application*: E, WB, IP

Mouse Anti-DENR Recombinant Antibody (D0703) (V2LY-0425-LY177)

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Target: DENR

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse, Rat, Dog

Clone: D0703

Application*: WB, IP, IF

Mouse Anti-DENR Recombinant Antibody (CAP621) (CBMAB-AP1848LY)

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Target: DENR

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CAP621

Application*: FC, IF, IHC, WB

Recombinant Mouse Anti-DENR Antibody (CBAb081) (CBMAB-Ab081-LY)

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Target: DENR

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBAb081

Application*: WB, IH, IF, FC

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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