DENR
This gene encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. This gene was also shown to have increased expression in cells overexpressing HER-2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF-2 and the initiator tRNA-Met, directs the ribosome to the proper translation start site. Proteins similar to SUI have been found in mammals, insects, and plants. [provided by RefSeq, Jul 2008]
Full Name
Density Regulated Re-Initiation And Release Factor
Function
May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1.
Biological Process
Formation of translation preinitiation complex Source: UniProtKB
IRES-dependent viral translational initiation Source: UniProtKB
Ribosome disassembly Source: UniProtKB
Translation reinitiation Source: GO_Central
IRES-dependent viral translational initiation Source: UniProtKB
Ribosome disassembly Source: UniProtKB
Translation reinitiation Source: GO_Central
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Anti-DENR antibodies
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Target: DENR
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1H3
Application*: WB
Target: DENR
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 1542CT106.51.79
Application*: WB, P, IC, IF, F
Target: DENR
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CAP621
Application*: F, IF, IH, WB
Target: DENR
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBAb081
Application*: E, WB
Target: DENR
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: D0704
Application*: E, WB, IP
Target: DENR
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat, Dog
Clone: D0703
Application*: WB, IP, IF
Target: DENR
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CAP621
Application*: FC, IF, IHC, WB
Target: DENR
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBAb081
Application*: WB, IH, IF, FC
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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