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DNAJC24

Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH4 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004 [PubMed 15485916]).

Full Name

DnaJ Heat Shock Protein Family (Hsp40) Member C24

Function

Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron-bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta).

Biological Process

Chaperone-mediated protein folding Source: UniProtKB
Peptidyl-diphthamide biosynthetic process from peptidyl-histidine Source: UniProtKB-UniPathway
Positive regulation of ATPase activity Source: UniProtKB

Cellular Location

Cytoskeleton

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Anti-DNAJC24 antibodies

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Mouse Anti-DNAJC24 Recombinant Antibody (CBWJZ-059) (CBMAB-Z0128-WJ)

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Target: DNAJC24

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBWJZ-059

Application*: WB, IP, IF, E

Mouse Anti-DNAJC24 Recombinant Antibody (CBWJZ-059) (V2LY-0425-LY653)

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Target: DNAJC24

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBWJZ-059

Application*: WB, IP, IF, E

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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