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DNAJC5

DNAJC5 (DnaJ Heat Shock Protein Family (Hsp40) Member C5) is a Protein Coding gene. Diseases associated with DNAJC5 include Ceroid Lipofuscinosis, Neuronal, 4B, Autosomal Dominant and Ceroid Storage Disease.
Full Name
DnaJ Heat Shock Protein Family (Hsp40) Member C5; DnaJ (Hsp40) Homolog, Subfamily C, Member; Ceroid-Lipofuscinosis Neuronal Protein; CLN4; Ceroid-Lipofuscinosis, Neuronal 4 (Kufs Disease) 2
DnaJ Homolog Subfamily C Member; Cysteine String Protein Alpha 3; Cysteine String Protein 4
Function
Acts as a general chaperone in regulated exocytosis (By similarity).

Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity).

Involved in the calcium-mediated control of a late stage of exocytosis (By similarity).

May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity).
Biological Process
Chaperone-mediated protein folding Source: Ensembl
Exocytosis Source: ParkinsonsUK-UCL
Negative regulation of neuron apoptotic process Source: Ensembl
Regulated exocytosis Source: ParkinsonsUK-UCL
Regulation of synaptic vesicle cycle Source: Ensembl
Synaptic vesicle exocytosis Source: ParkinsonsUK-UCL
Cellular Location
Cell membrane; Cytosol; Membrane; Chromaffin granule membrane; Melanosome. The association with membranes is regulated by palmitoylation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065).
Involvement in disease
Ceroid lipofuscinosis, neuronal, 4B (CLN4B):
An adult-onset neuronal ceroid lipofuscinosis. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy. CLN4B has no visual involvement and is characterized by seizures and other neurologic symptoms.
PTM
Ser-10 phosphorylation induces an order-to-disorder transition triggering the interaction with Lys-58 (PubMed:27452402). This conformational switch modulates DNAJC5's cellular functions by reducing binding to syntaxin and synaptogamin without altering HSC70 interactions (PubMed:27452402).
Palmitoylated. Could be palmitoylated by DHHC3, DHHC7, DHHC15 and DHHC17. Palmitoylation occurs probably in the cysteine-rich domain and regulates DNAJC5 membrane attachment.

Anti-DNAJC5 antibodies

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Target: DNAJC5
Host: Mouse
Antibody Isotype: IgG1
Specificity: P. vivax
Clone: CBMY-C0180
Application*: E, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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