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DPP9

This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the activity of this protein is similar to that of dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the regulation of the activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. Several transcript variants of this gene have been described but not fully characterized.
Full Name
Dipeptidyl Peptidase 9
Function
Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:12662155, PubMed:16475979, PubMed:19667070, PubMed:30291141, PubMed:29382749).

Acts as an inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis: inhibits pyroptosis by preventing activation of NLRP1 and CARD8 via an unknown mechanism (PubMed:27820798, PubMed:30291141, PubMed:29967349, PubMed:31525884, PubMed:32796818).
Cellular Location
Isoform 1: Cytosol
Isoform 2: Nucleus
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Anti-DPP9 antibodies

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Mouse Anti-DPP9 Recombinant Antibody (1G9) (CBMAB-D1611-YC)

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Target: DPP9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Dog, Monkey
Clone: 1G9
Application*: WB, P, F
Datasheet SDS

Mouse Anti-DPP9 Recombinant Antibody (CBYCD-394) (CBMAB-D1622-YC)

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Target: DPP9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYCD-394
Application*: WB, IC
Datasheet SDS

Mouse Anti-DPP9 Recombinant Antibody (6A12) (CBMAB-D1621-YC)

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Target: DPP9
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Dog
Clone: 6A12
Application*: F, IH, WB
Datasheet SDS

Mouse Anti-DPP9 Recombinant Antibody (5E9) (CBMAB-D1620-YC)

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Target: DPP9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5E9
Application*: WB, F, IC, IF
Datasheet SDS

Mouse Anti-DPP9 Recombinant Antibody (4C10) (CBMAB-D1616-YC)

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Target: DPP9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Monkey
Clone: 4C10
Application*: WB
Datasheet SDS

Mouse Anti-DPP9 Recombinant Antibody (2D6) (CBMAB-D1613-YC)

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Target: DPP9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog
Clone: 2D6
Application*: WB
Datasheet SDS

Mouse Anti-DPP9 Recombinant Antibody (2D4) (CBMAB-D1612-YC)

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Target: DPP9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2D4
Application*: IF, WB
Datasheet SDS

Mouse Anti-DPP9 Recombinant Antibody (CBYCD-394) (V2LY-0425-LY873)

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Target: DPP9
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYCD-394
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-DPP9 Recombinant Antibody (6A12) (V2LY-0425-LY872)

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Target: DPP9
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat, Dog
Clone: 6A12
Application*: F, IH, WB
Datasheet SDS

Mouse Anti-DPP9 Recombinant Antibody (5E9) (V2LY-0425-LY871)

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Target: DPP9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 5E9
Application*: WB, F, IF
Datasheet SDS

Mouse Anti-DPP9 Recombinant Antibody (4C10) (V2LY-0425-LY870)

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Target: DPP9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Monkey
Clone: 4C10
Application*: WB
Datasheet SDS

Mouse Anti-DPP9 Recombinant Antibody (2D6) (V2LY-0425-LY869)

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Target: DPP9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Dog
Clone: 2D6
Application*: WB
Datasheet SDS

Mouse Anti-DPP9 Recombinant Antibody (D1612) (V2LY-0425-LY868)

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Target: DPP9
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: D1612
Application*: IF, WB
Datasheet SDS

Mouse Anti-DPP9 Recombinant Antibody (D1611) (V2LY-0425-LY867)

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Target: DPP9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: D1611
Application*: WB, IP, IF
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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