Mouse Anti-DPP9 Recombinant Antibody (2D6) (V2LY-0425-LY869)

Name: Mouse Anti-DPP9 Recombinant Antibody (2D6)
SKU: V2LY-0425-LY869
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2D6

Application

Immunogen

Full length recombinant protein of human DPP9.

Host Species

Mouse

Specificity

Human, Mouse, Rat, Dog

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

BSA & Glycerol & PBS

Preservative

Sodium Azide

Concentration

1 mg/ml

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Dipeptidyl Peptidase 9

Entrez Gene ID

Human	91039
Dog	485033

UniProt ID

Human	Q86TI2
Dog	E2R8Z1

Function

Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:12662155, PubMed:16475979, PubMed:19667070, PubMed:30291141, PubMed:29382749).

Acts as an inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis: inhibits pyroptosis by preventing activation of NLRP1 and CARD8 via an unknown mechanism (PubMed:27820798, PubMed:30291141, PubMed:29967349, PubMed:31525884, PubMed:32796818).

Cellular Location

Isoform 1: Cytosol
Isoform 2: Nucleus

Silva-Garcia, M., Bolgi, O., Ross, B., Pilla, E., Kari, V., Killisch, M., ... & Geiss-Friedlander, R. (2020). Dipeptidyl peptidase 9 triggers BRCA2 degradation by the N-degron pathway to promote DNA-damage repair. bioRxiv.

Wu, Q. Q., Zhao, M., Huang, G. Z., Zheng, Z. N., Chen, Y., Zeng, W. S., & Lv, X. Z. (2020). Fibroblast activation protein (FAP) overexpression induces epithelial–mesenchymal transition (EMT) in oral squamous cell carcinoma by down-regulating dipeptidyl peptidase 9 (DPP9). OncoTargets and therapy, 13, 2599.

Saso, K., Miyoshi, N., Fujino, S., Sasaki, M., Yasui, M., Ohue, M., ... & Eguchi, H. (2020). Dipeptidyl Peptidase 9 Increases Chemoresistance and is an Indicator of Poor Prognosis in Colorectal Cancer. Annals of Surgical Oncology, 27(11), 4337-4347.

Brunetti, M., Holth, A., Panagopoulos, I., Staff, A. C., Micci, F., & Davidson, B. (2019). Expression and clinical role of the dipeptidyl peptidases DPP8 and DPP9 in ovarian carcinoma. Virchows Archiv, 474(2), 177-185.

Zhong, F. L., Robinson, K., Teo, D. E. T., Tan, K. Y., Lim, C., Harapas, C. R., ... & Reversade, B. (2018). Human DPP9 represses NLRP1 inflammasome and protects against autoinflammatory diseases via both peptidase activity and FIIND domain binding. Journal of Biological Chemistry, 293(49), 18864-18878.

Ross, B., Krapp, S., Augustin, M., Kierfersauer, R., Arciniega, M., Geiss-Friedlander, R., & Huber, R. (2018). Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer. Proceedings of the National Academy of Sciences, 115(7), E1437-E1445.

Gabrilovac, J., Čupić, B., Zapletal, E., Kraus, O., & Jakić-Razumović, J. (2017). Dipeptidyl peptidase 9 (DPP9) in human skin cells. Immunobiology, 222(2), 327-342.

Tang, Z., Li, J., Shen, Q., Feng, J., Liu, H., Wang, W., ... & Ni, S. (2017). Contribution of upregulated dipeptidyl peptidase 9 (DPP9) in promoting tumoregenicity, metastasis and the prediction of poor prognosis in non‐small cell lung cancer (NSCLC). International Journal of Cancer, 140(7), 1620-1632.

Zapletal, E., Cupic, B., & Gabrilovac, J. (2017). Expression, subcellular localisation, and possible roles of dipeptidyl peptidase 9 (DPP9) in murine macrophages. Cell Biochemistry and Function, 35(2), 124-137.

Gall, M. G., & Gorrell, M. D. (2017). The multifunctional post-proline dipeptidyl peptidase, DPP9, in mice, cell biology and immunity. In Pathophysiological aspects of proteases (pp. 23-45). Springer, Singapore.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Alternative Versions

Mouse Anti-DPP9 Recombinant Antibody (2D6) (CAT#: CBMAB-D1613-YC)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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