DUSP5

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus. [provided by RefSeq]
Full Name
dual specificity phosphatase 5
Research Area
Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1.
Biological Process
Activation of MAPK activity Source: Reactome
Dephosphorylation Source: UniProtKB
Endoderm formation Source: GO_Central
Inactivation of MAPK activity Source: GO_Central
MAPK cascade Source: Reactome
Peptidyl-threonine dephosphorylation Source: UniProtKB
Peptidyl-tyrosine dephosphorylation Source: UniProtKB
Protein dephosphorylation Source: GO_Central
Cellular Location
Nucleus
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Anti-DUSP5 antibodies

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Mouse Anti-DUSP5 Recombinant Antibody (2F3) (CBMAB-D1911-YC)

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Target: DUSP5
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2F3
Application*: IF, WB, E
Datasheet SDS

Mouse Anti-DUSP5 Recombinant Antibody (8C122) (CBMAB-D1909-YC)

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Target: DUSP5
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 8C122
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-DUSP5 Recombinant Antibody (6D1) (CBMAB-D1908-YC)

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Target: DUSP5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 6D1
Application*: E, WB
Datasheet SDS

Mouse Anti-DUSP5 Recombinant Antibody (D1910) (V2LY-0425-LY1085)

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Target: DUSP5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: D1910
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-DUSP5 Recombinant Antibody (4C8) (V2LY-0425-LY1082)

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Target: DUSP5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4C8
Application*: IF, WB, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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