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DUSP5

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus. [provided by RefSeq]

Full Name

dual specificity phosphatase 5

Research Area

Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1.

Biological Process

Activation of MAPK activity Source: Reactome
Dephosphorylation Source: UniProtKB
Endoderm formation Source: GO_Central
Inactivation of MAPK activity Source: GO_Central
MAPK cascade Source: Reactome
Peptidyl-threonine dephosphorylation Source: UniProtKB
Peptidyl-tyrosine dephosphorylation Source: UniProtKB
Protein dephosphorylation Source: GO_Central

Cellular Location

Nucleus

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Anti-DUSP5 antibodies

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Mouse Anti-DUSP5 Recombinant Antibody (2F3) (CBMAB-D1911-YC)

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Target: DUSP5

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 2F3

Application*: IF, WB, E

Mouse Anti-DUSP5 Recombinant Antibody (8C122) (CBMAB-D1909-YC)

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Target: DUSP5

Host: Mouse

Antibody Isotype: IgG3, κ

Specificity: Human

Clone: 8C122

Application*: WB, IP, IF, E

Mouse Anti-DUSP5 Recombinant Antibody (6D1) (CBMAB-D1908-YC)

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Target: DUSP5

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 6D1

Application*: E, WB

Mouse Anti-DUSP5 Recombinant Antibody (D1910) (V2LY-0425-LY1085)

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Target: DUSP5

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: D1910

Application*: WB, IP, IF, E

Mouse Anti-DUSP5 Recombinant Antibody (4C8) (V2LY-0425-LY1082)

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Target: DUSP5

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 4C8

Application*: IF, WB, E

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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