EXOC5

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity.

Full Name

Exocyst Complex Component 5

Research Area

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Biological Process

Epithelial cell apoptotic process Source: Ensembl
Establishment of planar polarity Source: Ensembl
Exocytosis Source: GO_Central
Golgi to plasma membrane transport Source: GO_Central
Non-motile cilium assembly Source: Ensembl
Post-Golgi vesicle-mediated transport Source: ProtInc
Protein localization to plasma membrane Source: Ensembl
Protein transport Source: UniProtKB-KW

Cellular Location

Cytoplasm; Midbody. Localization at the midbody requires the presence of RALA, EXOC2 and EXOC3.