Mouse Anti-EXOC5 Recombinant Antibody (CBXS-2098) (V2LY-0825-LY938)

Name: Mouse Anti-EXOC5 Recombinant Antibody (CBXS-2098)
SKU: V2LY-0825-LY938
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXS-2098

Application

WB, IP, IF, ELISA

Immunogen

Amino acids 1-300 mapping at the N-terminus of human Sec10.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500
ELISA	1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, gelatin

Preservative

Sodium azide

Concentration

0.2 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Exocyst Complex Component 5

Entrez Gene ID

Human	10640
Mouse	105504
Rat	60627

UniProt ID

Human	O00471
Mouse	Q3TPX4
Rat	P97878

Research Area

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Biological Process

Epithelial cell apoptotic process Source: Ensembl
Establishment of planar polarity Source: Ensembl
Exocytosis Source: GO_Central
Golgi to plasma membrane transport Source: GO_Central
Non-motile cilium assembly Source: Ensembl
Post-Golgi vesicle-mediated transport Source: ProtInc
Protein localization to plasma membrane Source: Ensembl
Protein transport Source: UniProtKB-KW

Cellular Location

Cytoplasm; Midbody. Localization at the midbody requires the presence of RALA, EXOC2 and EXOC3.

Rohrer, B., Biswal, M. R., Obert, E., Dang, Y., Su, Y., Zuo, X., ... & Lipschutz, J. H. (2021). Conditional Loss of the Exocyst Component Exoc5 in Retinal Pigment Epithelium (RPE) Results in RPE Dysfunction, Photoreceptor Cell Degeneration, and Decreased Visual Function. International journal of molecular sciences, 22(10), 5083.

Sion, B. (2020). Role of the EXOC5 Protein In the RPE and Retina of Mice and Zebrafish.

Lee, B., Baek, J. I., Min, H., Bae, S. H., Moon, K., Min-A, K., ... & Un-Kyung, K. (2019). Correction to: Exocyst Complex Member EXOC5 Is Required for Survival of Hair Cells and Spiral Ganglion Neurons and Maintenance of Hearing. Molecular neurobiology, 56(3), 2300-2300.

Lee, B., Baek, J. I., Min, H., Bae, S. H., Moon, K., Kim, M. A., ... & Kim, U. K. (2018). Exocyst complex member EXOC5 is required for survival of hair cells and spiral ganglion neurons and maintenance of hearing. Molecular neurobiology, 55(8), 6518-6532.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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