EXOSC10

EXOSC10 (Exosome Component 10) is a Protein Coding gene. Diseases associated with EXOSC10 include Systemic Scleroderma and Collagen Disease. Among its related pathways are Gene Expression and rRNA processing in the nucleus and cytosol. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding.

exosome component 10

Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity (By similarity).

EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPHOSPH6 with the RNA exosome involved in the maturation of 5.8S rRNA.

CUT catabolic process Source: UniProtKB
Dosage compensation by inactivation of X chromosome Source: Ensembl
Exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: GO_Central
Histone mRNA catabolic process Source: UniProtKB
Maturation of 5.8S rRNA Source: UniProtKB
Negative regulation of telomere maintenance via telomerase Source: BHF-UCL
Nuclear mRNA surveillance Source: UniProtKB
Nuclear polyadenylation-dependent antisense transcript catabolic process Source: GO_Central
Nuclear polyadenylation-dependent CUT catabolic process Source: GO_Central
Nuclear polyadenylation-dependent rRNA catabolic process Source: UniProtKB
Nuclear polyadenylation-dependent snoRNA catabolic process Source: GO_Central
Nuclear polyadenylation-dependent snRNA catabolic process Source: GO_Central
Nuclear polyadenylation-dependent tRNA catabolic process Source: GO_Central
Nuclear retention of unspliced pre-mRNA at the site of transcription Source: UniProtKB
Nuclear-transcribed mRNA catabolic process Source: UniProtKB
Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: UniProtKB-KW
Polyadenylation-dependent snoRNA 3'-end processing Source: GO_Central
Regulation of telomerase RNA localization to Cajal body Source: BHF-UCL
rRNA processing Source: Reactome

Nucleolus; Nucleus; Cytoplasm. Strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form.