EYA3

This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator and have a role during development. It can act as a mediator of chemoresistance and cell survival in Ewing sarcoma cells, where this gene is up-regulated via a micro-RNA that binds to the 3' UTR of the transcript. A similar protein in mice acts as a transcriptional activator. Alternative splicing of this gene results in multiple transcript variants.

Eya Transcriptional Coactivator And Phosphatase 3

Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (PubMed:19234442, PubMed:19351884).

Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity).

May be involved in development of the eye.

Anatomical structure development Source: GO_Central
Anatomical structure morphogenesis Source: ProtInc
Cell differentiation Source: GO_Central
Double-strand break repair Source: UniProtKB
Histone dephosphorylation Source: UniProtKB
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: GO_Central
Positive regulation of DNA repair Source: UniProtKB
Response to ionizing radiation Source: UniProtKB
Visual perception Source: ProtInc

Nucleus; Cytoplasm. Localizes at sites of DNA damage at double-strand breaks (DSBs) (PubMed:19234442). With decreasing efficiency, translocalized to the nucleus by SIX2 and SIX5, and SIX4, respectively (By similarity).

Ser-266 phosphorylation is required for localization at sites of DNA damage and directing interaction with H2AX.