FCRL2

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains one immunoreceptor-tyrosine activation motif and two immunoreceptor-tyrosine inhibitory motifs. This protein may be a prognostic marker for chronic lymphocytic leukemia. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Fc Receptor Like 2

May have an regulatory role in normal and neoplastic B cell development.

Cell-cell signaling Source: UniProtKB
Cell surface receptor signaling pathway Source: GO_Central

Cell membrane

Extracellular: 20-401
Helical: 402-422
Cytoplasmic: 423-508

Isoform 2 is N- and O-glycosylated, and phosphorylated.