Mouse Anti-FCRL2 Recombinant Antibody (CBXF-3306) (CBMAB-F0140-CQ)

Name: Mouse Anti-FCRL2 Recombinant Antibody (CBXF-3306)
SKU: CBMAB-F0140-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-3306

Application

ELISA

Immunogen

Human CD307b/FCRL2/IRTA4.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Fc Receptor Like 2

Introduction

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains one immunoreceptor-tyrosine activation motif and two immunoreceptor-tyrosine inhibitory motifs. This protein may be a prognostic marker for chronic lymphocytic leukemia. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Entrez Gene ID

79368

UniProt ID

Q96LA5

Alternative Names

Fc Receptor Like 2; Immunoglobulin Receptor Translocation-Associated Protein 4; SH2 Domain-Containing Phosphatase Anchor Protein 1; Fc Receptor Homolog 2; IFGP Family Protein 4; SPAP1; FCRH2; IFGP4; IRTA4; SH2 Domain Containing Phosphatase Anchor Protein 1; Immune Receptor Translocation-Associated Protein 4;

Research Area

May have an regulatory role in normal and neoplastic B cell development.

Biological Process

Cell-cell signaling Source: UniProtKB
Cell surface receptor signaling pathway Source: GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 20-401
Helical: 402-422
Cytoplasmic: 423-508

PTM

Isoform 2 is N- and O-glycosylated, and phosphorylated.

Shea, L. K., Honjo, K., Redden, D. T., Tabengwa, E., Li, R., Li, F. J., ... & Davis, R. S. (2019). Fc receptor-like 2 (FCRL2) is a novel marker of low-risk CLL and refines prognostication based on IGHV mutation status. Blood cancer journal, 9(6), 1-5.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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