FGF18

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. [provided by RefSeq, Jul 2008]

Fibroblast Growth Factor 18

Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation.

Anatomical structure morphogenesis Source: ProtInc
Angiogenesis Source: Ensembl
Animal organ morphogenesis Source: GO_Central
Cell-cell signaling Source: ProtInc
Cell differentiation Source: GO_Central
Chondrocyte development Source: Ensembl
Endochondral ossification Source: Ensembl
Fibroblast growth factor receptor signaling pathway Source: GO_Central
Intramembranous ossification Source: Ensembl
Lung development Source: Ensembl
Positive regulation of angiogenesis Source: BHF-UCL
Positive regulation of blood vessel endothelial cell migration Source: BHF-UCL
Positive regulation of cell population proliferation Source: GO_Central
Positive regulation of chondrocyte differentiation Source: Ensembl
Positive regulation of endothelial cell chemotaxis to fibroblast growth factor Source: UniProtKB
Positive regulation of ERK1 and ERK2 cascade Source: Ensembl
Positive regulation of gene expression Source: GO_Central
Positive regulation of MAP kinase activity Source: UniProtKB
Positive regulation of protein phosphorylation Source: GO_Central
Positive regulation of vascular endothelial growth factor receptor signaling pathway Source: Ensembl
Regulation of cell migration Source: GO_Central
Signal transduction Source: ProtInc

Secreted