Mouse Recombinant FGF18 protein, His Tag (V2LY-0526-LY8313)

Name: Mouse Recombinant FGF18 protein, His Tag
SKU: V2LY-0526-LY8313
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Mouse

Tag

His Tag

Protein Construction

This product is Mouse Recombinant FGF18 protein, His Tag consist of Amino Acid: 1-207 and predicts a molecular mass of 22.5 kDa.

Molecule Mass

22.5 kDa

Sequence

Amino Acid: 1-207

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Fibroblast Growth Factor 18

Research Area

Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation.

Biological Process

Anatomical structure morphogenesis Source: ProtInc
Angiogenesis Source: Ensembl
Animal organ morphogenesis Source: GO_Central
Cell-cell signaling Source: ProtInc
Cell differentiation Source: GO_Central
Chondrocyte development Source: Ensembl
Endochondral ossification Source: Ensembl
Fibroblast growth factor receptor signaling pathway Source: GO_Central
Intramembranous ossification Source: Ensembl
Lung development Source: Ensembl
Positive regulation of angiogenesis Source: BHF-UCL
Positive regulation of blood vessel endothelial cell migration Source: BHF-UCL
Positive regulation of cell population proliferation Source: GO_Central
Positive regulation of chondrocyte differentiation Source: Ensembl
Positive regulation of endothelial cell chemotaxis to fibroblast growth factor Source: UniProtKB
Positive regulation of ERK1 and ERK2 cascade Source: Ensembl
Positive regulation of gene expression Source: GO_Central
Positive regulation of MAP kinase activity Source: UniProtKB
Positive regulation of protein phosphorylation Source: GO_Central
Positive regulation of vascular endothelial growth factor receptor signaling pathway Source: Ensembl
Regulation of cell migration Source: GO_Central
Signal transduction Source: ProtInc

Cellular Location

Secreted

Tong, G., Chen, X., Lee, J., Fan, J., Li, S., Zhu, K., ... & Jin, L. (2022). Fibroblast growth factor 18 attenuates liver fibrosis and HSCs activation via the SMO-LATS1-YAP pathway. Pharmacological Research, 178, 106139.

Estienne, A., Relav, L., Benkoura, M., Monniaux, D., Morin, F., Fabre, S., & Price, C. A. (2022). Endothelial cell‐derived fibroblast growth factor‐18 regulates ovarian function in sheep. Journal of Cellular Physiology.

Li, X. G., Song, X., Wang, J. Y., Sun, C. H., Li, Z. Q., Meng, L. L., & Chi, S. H. (2021). Fibroblast growth factor 18 alleviates hyperoxia-induced lung injury in mice by adjusting oxidative stress and inflammation. European Review for Medical and Pharmacological Sciences, 25(3), 1485-1494.

Li, J., Wang, X., Ruan, G., Zhu, Z., & Ding, C. (2021). Sprifermin: a recombinant human fibroblast growth factor 18 for the treatment of knee osteoarthritis. Expert Opinion on Investigational Drugs, 30(9), 923-930.

da Silva, R. B., Yang, M. Y., Caixeta, E. S., Castilho, A. C., Amorim, R. L., Price, C. A., ... & Buratini, J. (2019). Fibroblast growth factor 18 regulates steroidogenesis in fetal bovine ovarian tissue in vitro. Molecular Reproduction and Development, 86(2), 166-174.

Häckel, S., Zolfaghar, M., Du, J., Hoppe, S., Benneker, L. M., Garstka, N., ... & Li, Z. (2019). Fibrin-hyaluronic acid hydrogel (RegenoGel) with fibroblast growth factor-18 for in vitro 3D culture of human and bovine nucleus pulposus cells. International journal of molecular sciences, 20(20), 5036.

Hagan, A. S., Boylan, M., Smith, C., Perez‐Santamarina, E., Kowalska, K., Hung, I. H., ... & Ornitz, D. M. (2019). Generation and validation of novel conditional flox and inducible Cre alleles targeting fibroblast growth factor 18 (Fgf18). Developmental Dynamics, 248(9), 882-893.

Yao, X., Jing, X., Ye, Y., Guo, J., Sun, K., & Guo, F. (2019). Fibroblast growth factor 18 exerts anti-osteoarthritic effects through PI3K-AKT signaling and mitochondrial fusion and fission. Pharmacological research, 139, 314-324.

Yu, Z., Lou, L., & Zhao, Y. (2018). Fibroblast growth factor 18 promotes the growth, migration and invasion of MDA‑MB‑231 cells. Oncology reports, 40(2), 704-714.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant FGF18 protein, His Tag (CAT#: V2LY-0526-LY4056)

Rat Fgf18 ELISA Kit (CAT#: V2LY-0626-LY2209)

Mouse Fgf18 ELISA Kit (CAT#: V2LY-0626-LY2351)

Human FGF18 ELISA Kit (CAT#: V2LY-0626-LY4582)

Related Products

Human Recombinant FGF18 protein, His Tag (CAT#: V2LY-0526-LY4056)

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Mouse Anti-FGF18 Recombinant Antibody (CF167) (CAT#: V2LY-0925-LY1478)

Mouse Anti-FGF18 Recombinant Antibody (320) (CAT#: V2LY-0925-LY1479)

Rat Fgf18 ELISA Kit (CAT#: V2LY-0626-LY2209)

Human FGF18 ELISA Kit (CAT#: V2LY-0626-LY4582)

Mouse Anti-FGF18 Recombinant Antibody (CBXF-2196) (CAT#: V2LY-0925-LY1477)

Mouse Anti-FGF18 Recombinant Antibody (CBWJZ-068) (CAT#: V2LY-0925-LY1475)

Mouse Fgf18 ELISA Kit (CAT#: V2LY-0626-LY2351)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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