FMN1

This gene belongs to the formin homology family and encodes a protein that has a role in the formation of adherens junction and the polymerization of linear actin cables. The homologous gene in mouse is associated with limb deformity. Alternatively spliced transcript variants have been found for this gene.

formin 1

Plays a role in the formation of adherens junction and the polymerization of linear actin cables.

Actin nucleation Source: InterPro
Forelimb morphogenesis Source: Ensembl
Gene expression Source: Ensembl
Hindlimb morphogenesis Source: Ensembl
Positive regulation of actin nucleation Source: Ensembl
Positive regulation of focal adhesion assembly Source: Ensembl
Skeletal system morphogenesis Source: Ensembl
Ureteric bud invasion Source: Ensembl

Cell membrane; Cytoplasm; Nucleus; Adherens junction. Localization to the adherens junctions is alpha-catenin-dependent. Also localizes to F-actin bundles originating from adherens junctions and to microtubules (By similarity).

Phosphorylated on serine and possibly threonine residues.