FPR3

FPR3 (Formyl Peptide Receptor 3) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and N-formyl peptide receptor activity. An important paralog of this gene is FPR2.

Full Name

Formyl Peptide Receptor 3

Function

Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Acts as a receptor for humanin (PubMed:15465011).

Biological Process

Chemotaxis Source: UniProtKB-KW
Complement receptor mediated signaling pathway Source: GO_Central
Inflammatory response Source: GO_Central
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_Central
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Signal transduction Source: ProtInc

Cellular Location

Cell membrane

Topology

Extracellular: 1-27
Helical: 28-50
Cytoplasmic: 51-61
Helical: 62-83
Extracellular: 84-100
Helical: 101-121
Cytoplasmic: 122-140
Helical: 141-162
Extracellular: 163-205
Helical: 206-226
Cytoplasmic: 227-242
Helical: 243-266
Extracellular: 267-286
Helical: 287-306
Cytoplasmic: 307-353

Anti-FPR3 antibodies

Mouse Anti-FPR3 Recombinant Antibody (CBXF-2669) (CBMAB-F0151-CQ)

Datasheet

SDS

Target: FPR3

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXF-2669

Application*: F

Rabbit Anti-FPR3 Recombinant Antibody (CBXF-1093) (CBMAB-F0970-CQ)

Datasheet

SDS

Target: FPR3

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-1093

Application*: WB, F

Mouse Anti-FPR3 Recombinant Antibody (CBXF-3638) (CBMAB-F2874-CQ)

Datasheet

SDS

Target: FPR3

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXF-3638

Application*: F

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)