FPR3

FPR3 (Formyl Peptide Receptor 3) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and N-formyl peptide receptor activity. An important paralog of this gene is FPR2.

Formyl Peptide Receptor 3

Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Acts as a receptor for humanin (PubMed:15465011).

Chemotaxis Source: UniProtKB-KW
Complement receptor mediated signaling pathway Source: GO_Central
Inflammatory response Source: GO_Central
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_Central
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Signal transduction Source: ProtInc

Cell membrane

Extracellular: 1-27
Helical: 28-50
Cytoplasmic: 51-61
Helical: 62-83
Extracellular: 84-100
Helical: 101-121
Cytoplasmic: 122-140
Helical: 141-162
Extracellular: 163-205
Helical: 206-226
Cytoplasmic: 227-242
Helical: 243-266
Extracellular: 267-286
Helical: 287-306
Cytoplasmic: 307-353