Mouse Anti-FPR3 Recombinant Antibody (CBXF-2669) (CBMAB-F0151-CQ)

This product is a mouse antibody that recognizes FPR3. The antibody CBXF-2669 can be used for immunoassay techniques such as: FC.
See all FPR3 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBXF-2669

Antibody Isotype

IgG2b

Application

Basic Information

Immunogen

HEK293 human embryonic kidney cell line transfected with human FPRL2, Met1-Met352, Accession # P25089

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

A saline solution, BSA

Preservative

0.05% sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Formyl Peptide Receptor 3

Introduction

FPR3 (Formyl Peptide Receptor 3) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and N-formyl peptide receptor activity. An important paralog of this gene is FPR2.

Entrez Gene ID

2359

UniProt ID

P25089

Alternative Names

Formyl Peptide Receptor 3; Formyl Peptide Receptor-Like 2; FMLP-Related Receptor II; FMLP-R-II; FPRH1; FPRL2;

Function

Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Acts as a receptor for humanin (PubMed:15465011).

Biological Process

Chemotaxis Source: UniProtKB-KW
Complement receptor mediated signaling pathway Source: GO_Central
Inflammatory response Source: GO_Central
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_Central
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Signal transduction Source: ProtInc

Cellular Location

Cell membrane

Topology

Extracellular: 1-27
Helical: 28-50
Cytoplasmic: 51-61
Helical: 62-83
Extracellular: 84-100
Helical: 101-121
Cytoplasmic: 122-140
Helical: 141-162
Extracellular: 163-205
Helical: 206-226
Cytoplasmic: 227-242
Helical: 243-266
Extracellular: 267-286
Helical: 287-306
Cytoplasmic: 307-353

References

Lee, C., Han, J., & Jung, Y. (2023). Formyl peptide receptor 2 is an emerging modulator of inflammation in the liver. Experimental & Molecular Medicine, 1-8.

Klaver, D., Posch, B., Geisler, A., Hermann, M., Reider, N., & Heufler, C. (2020). Peptides from allergenic lipocalins bind to formyl peptide receptor 3 in human dendritic cells to mediate TH2 immunity. Journal of Allergy and Clinical Immunology, 145(2), 654-665.

Lee, H. Y., Kim, H. S., Jeong, Y. S., Kim, J. C., Bae, Y. S., Jo, Y. H., ... & Bae, Y. S. (2020). A membrane-tethering pepducin derived from formyl peptide receptor 3 shows strong therapeutic effects against sepsis. Biochemical and Biophysical Research Communications, 524(1), 156-162.

Nawaz, M. I., Rezzola, S., Tobia, C., Coltrini, D., Belleri, M., Mitola, S., ... & Presta, M. (2020). D-Peptide analogues of Boc-Phe-Leu-Phe-Leu-Phe-COOH induce neovascularization via endothelial N-formyl peptide receptor 3. Angiogenesis, 23(3), 357-369.

Chen, Y. C., Lin, M. C., Lee, C. H., Liu, S. F., Wang, C. C., Fang, W. F., ... & Chen, H. C. (2018). Defective formyl peptide receptor 2/3 and annexin A1 expressions associated with M2a polarization of blood immune cells in patients with chronic obstructive pulmonary disease. Journal of translational medicine, 16(1), 1-12.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Rabbit Anti-FPR3 Recombinant Antibody (CBXF-1093)

Mouse Anti-FPR3 Recombinant Antibody (CBXF-3638)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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