FUT7

The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X antigens. The encoded protein can direct the synthesis of the E-selectin-binding sialyl-Lewis X moiety. [provided by RefSeq]

Full Name

fucosyltransferase 7 (alpha (1,3) fucosyltransferase)

Function

Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal alpha2,3 sialylated lactosamine unit of a glycoprotein or a glycolipid-linked sialopolylactosamines chain through an alpha-1,3 glycosidic linkage and participates in the final fucosylation step in the biosynthesis of the sialyl Lewis X (sLe(x)), a carbohydrate involved in cell and matrix adhesion during leukocyte trafficking and fertilization (PubMed:8207002, PubMed:8752218, PubMed:8666674, PubMed:9299472, PubMed:9405391, PubMed:9473504, PubMed:9499379, PubMed:9461592, PubMed:15632313, PubMed:15926890, PubMed:18553500, PubMed:18402946, PubMed:11404359).

In vitro, also synthesizes sialyl-dimeric-Lex structures, from VIM-2 structures and both di-fucosylated and trifucosylated structures from mono-fucosylated precursors (PubMed:9499379).

However does not catalyze alpha 1-3 fucosylation when an internal alpha 1-3 fucosylation is present in polylactosamine chain and the fucosylation rate of the internal GlcNAc residues is reduced once fucose has been added to the distal GlcNAc (PubMed:9473504, PubMed:9499379).

Also catalyzes the transfer of a fucose from GDP-beta-fucose to the 6-sulfated a(2,3)sialylated substrate to produce 6-sulfo sLex mediating significant L-selectin-dependent cell adhesion (PubMed:10200296, PubMed:8752218).

Through sialyl-Lewis(x) biosynthesis, can control SELE- and SELP-mediated cell adhesion with leukocytes and allows leukocytes tethering and rolling along the endothelial tissue thereby enabling the leukocytes to accumulate at a site of inflammation (PubMed:10386892, PubMed:29138114, PubMed:8666674, PubMed:9473504, PubMed:9834120).

May enhance embryo implantation through sialyl Lewis X (sLeX)-mediated adhesion of embryo cells to endometrium (PubMed:18402946, PubMed:18553500).

May affect insulin signaling by upregulating the phosphorylation and expression of some signaling molecules involved in the insulin-signaling pathway through SLe(x) which is present on the glycans of the INSRR alpha subunit (PubMed:17229154).

Biological Process

CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation Source: Ensembl
Ceramide metabolic process Source: BHF-UCL
Embryo implantation Source: UniProtKB
Fucosylation Source: GO_Central
Inflammatory response Source: UniProtKB
Leukocyte migration involved in immune response Source: Ensembl
Leukocyte migration involved in inflammatory response Source: UniProtKB
L-fucose catabolic process Source: UniProtKB
Lymphocyte migration into lymphoid organs Source: Ensembl
Oligosaccharide biosynthetic process Source: Reactome
Positive regulation of cell adhesion Source: UniProtKB
Positive regulation of cell-cell adhesion Source: UniProtKB
Positive regulation of leukocyte adhesion to vascular endothelial cell Source: UniProtKB
Positive regulation of leukocyte tethering or rolling Source: UniProtKB
Protein glycosylation Source: UniProtKB
Regulation of cell adhesion molecule production Source: UniProtKB
Regulation of cell-cell adhesion Source: UniProtKB
Regulation of insulin receptor signaling pathway Source: UniProtKB
Regulation of leukocyte cell-cell adhesion Source: UniProtKB
Regulation of leukocyte tethering or rolling Source: UniProtKB
Regulation of neutrophil extravasation Source: Ensembl
Regulation of type IV hypersensitivity Source: UniProtKB

Cellular Location

Golgi stack membrane. Membrane-bound form in trans cisternae of Golgi.

Topology

Cytoplasmic: 1-14
Helical: 15-36
Lumenal: 36-342

PTM

N-glycosylated.