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Mouse Anti-FUT7 Recombinant Antibody (1C12) (CBMAB-A3235-LY)

The product is antibody recognizes FUT7. The antibody 1C12 immunoassay techniques such as: sELISA, ELISA.
See all FUT7 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1C12
Antibody Isotype
IgG2a, κ
Application
sELISA, ELISA

Basic Information

Immunogen
FUT7 (NP_004470, 262 a.a. ~ 342 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
Introduction
The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X antigens. The encoded protein can direct the synthesis of the E-selectin-binding sialyl-Lewis X moiety. [provided by RefSeq]
Entrez Gene ID
2529
UniProt ID
Q11130
Alternative Names
FucT-VII
Function
Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal alpha2,3 sialylated lactosamine unit of a glycoprotein or a glycolipid-linked sialopolylactosamines chain through an alpha-1,3 glycosidic linkage and participates in the final fucosylation step in the biosynthesis of the sialyl Lewis X (sLe(x)), a carbohydrate involved in cell and matrix adhesion during leukocyte trafficking and fertilization (PubMed:8207002, PubMed:8752218, PubMed:8666674, PubMed:9299472, PubMed:9405391, PubMed:9473504, PubMed:9499379, PubMed:9461592, PubMed:15632313, PubMed:15926890, PubMed:18553500, PubMed:18402946, PubMed:11404359).

In vitro, also synthesizes sialyl-dimeric-Lex structures, from VIM-2 structures and both di-fucosylated and trifucosylated structures from mono-fucosylated precursors (PubMed:9499379).

However does not catalyze alpha 1-3 fucosylation when an internal alpha 1-3 fucosylation is present in polylactosamine chain and the fucosylation rate of the internal GlcNAc residues is reduced once fucose has been added to the distal GlcNAc (PubMed:9473504, PubMed:9499379).

Also catalyzes the transfer of a fucose from GDP-beta-fucose to the 6-sulfated a(2,3)sialylated substrate to produce 6-sulfo sLex mediating significant L-selectin-dependent cell adhesion (PubMed:10200296, PubMed:8752218).

Through sialyl-Lewis(x) biosynthesis, can control SELE- and SELP-mediated cell adhesion with leukocytes and allows leukocytes tethering and rolling along the endothelial tissue thereby enabling the leukocytes to accumulate at a site of inflammation (PubMed:10386892, PubMed:29138114, PubMed:8666674, PubMed:9473504, PubMed:9834120).

May enhance embryo implantation through sialyl Lewis X (sLeX)-mediated adhesion of embryo cells to endometrium (PubMed:18402946, PubMed:18553500).

May affect insulin signaling by upregulating the phosphorylation and expression of some signaling molecules involved in the insulin-signaling pathway through SLe(x) which is present on the glycans of the INSRR alpha subunit (PubMed:17229154).
Biological Process
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation Source: Ensembl
Ceramide metabolic process Source: BHF-UCL
Embryo implantation Source: UniProtKB
Fucosylation Source: GO_Central
Inflammatory response Source: UniProtKB
Leukocyte migration involved in immune response Source: Ensembl
Leukocyte migration involved in inflammatory response Source: UniProtKB
L-fucose catabolic process Source: UniProtKB
Lymphocyte migration into lymphoid organs Source: Ensembl
Oligosaccharide biosynthetic process Source: Reactome
Positive regulation of cell adhesion Source: UniProtKB
Positive regulation of cell-cell adhesion Source: UniProtKB
Positive regulation of leukocyte adhesion to vascular endothelial cell Source: UniProtKB
Positive regulation of leukocyte tethering or rolling Source: UniProtKB
Protein glycosylation Source: UniProtKB
Regulation of cell adhesion molecule production Source: UniProtKB
Regulation of cell-cell adhesion Source: UniProtKB
Regulation of insulin receptor signaling pathway Source: UniProtKB
Regulation of leukocyte cell-cell adhesion Source: UniProtKB
Regulation of leukocyte tethering or rolling Source: UniProtKB
Regulation of neutrophil extravasation Source: Ensembl
Regulation of type IV hypersensitivity Source: UniProtKB
Cellular Location
Golgi stack membrane. Membrane-bound form in trans cisternae of Golgi.
Topology
Cytoplasmic: 1-14
Helical: 15-36
Lumenal: 36-342
PTM
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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